Burns : journal of the International Society for Burn Injuries
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We assessed whether a home fire safety intervention targeting families with newborn children in Jefferson County, Kentucky, reached those at severe risk using a cartographic model. Demographic and economic factors of 61 families were compared by census tract. Using geographic information systems (GIS), families were assigned a risk level (low, medium, high, or severe) based on the risk model. ⋯ Sixty-five tracts were identified as high or severe risk and in need of future intervention. The model yielded a way to prioritize at-risk families. GIS is a useful tool for examining whether prevention interventions reached those in the severe risk category.
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Platelet rich plasma (PRP) is rich in growth factors and has been shown to improve healing in a variety of wounds. We determined the effects of PRP on healing and scarring in full thickness porcine burns with and without tangential excision and grafting (TEG). ⋯ Addition of PRP had similar effects on reepithelialization and scarring of full thickness porcine burns as standard topical antibiotic ointment regardless of whether the burns underwent excision or grafting or the timing of excision and grafting.
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A major goal of burn management is to reduce the progression of necrosis in the zone of ischemia surrounding the central zone of necrosis. A rat comb burn model is often used to assess the progression of necrosis in the zone of ischemia. We compared various combinations of naproxen [NPX], N-acetyl cysteine [NAC], and tadalafil [TD] (a phosphodiesterase-5 inhibitor used as a vasodilator to treat erectile dysfunction) in a rat comb burn model to determine their effects on injury progression. ⋯ Daily oral therapy with tadalafil reduces necrosis in the unburned interspaces compared with naproxen, NAC, or their combination in a rat comb burn model. Addition of naproxen or NAC to tadalafil does not further reduce injury progression.