Current opinion in pediatrics
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This section focuses on issues in infectious disease that are commonly encountered in pediatric office practices. Dr. McCarthy discusses recent literature regarding the evaluation and management of acute fevers without apparent source on clinical examination in infants and children and the evaluation of children with prolonged fevers of unknown origin. ⋯ Klig and Chen (pp 121-126) review recent literature about lower respiratory infection in children. This section focuses on febrile children in whom a source of fever is not readily apparent on clinical examination. This issue is discussed in several contexts: recent developments concerning the epidemiology, pathophysiology, diagnostic approach, and therapy of febrile illnesses; children from 3 to 36 months of age with fever; infants younger than 90 days of age with fever; and children of any age with prolonged fever, usually lasting more than 7 to 10 days, for whom a diagnosis has not been established.
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Curr. Opin. Pediatr. · Feb 2003
ReviewRecombinant human activated protein C for the treatment of severe sepsis: is there a role in pediatrics?
Sepsis with organ failure (severe sepsis) remains an important cause of morbidity and mortality among children. The clinical pathophysiology of severe sepsis reflects a coordinated activation of the innate immune response, including elaboration of proinflammatory cytokines and the induction of the extrinsic pathway of coagulation (sepsis-induced coagulopathy). These proinflammatory and procoagulant pathways are linked, and are similarly coregulated by a number of proteins and factors, including protein C. ⋯ This deficiency is associated with poor outcomes, including multiple organ failure and mortality. Recently, recombinant activated protein C was shown to reduce the mortality of adults with severe sepsis, and is now approved for such use in the United States and Europe. The rationale for pediatric applications of protein C and ongoing clinical trials in children are reviewed.
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Lower respiratory infections (LRIs) continue to threaten the health of children worldwide and are exacerbated by global environmental problems such as air pollution [1]. In the developing world where nutrition remains poor and access to healthcare is scarce, LRIs are the most common cause of illness and death in children. Outcomes of LRI illness are far better in developed countries, but the overall morbidity of LRI is still high and may exceed that of other age groups [2]. ⋯ The recent literature details both progress and clinical dilemmas of LRI-related illnesses in children. Lower respiratory infection disease is considered to include the following entities: acute lower respiratory infections, pneumonia, atypical pneumonia, bronchitis, and bronchiolitis. This update will review current reports on the evaluation of children with LRIs, bacterial and viral LRIs, and sequelae of LRIs.
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Curr. Opin. Pediatr. · Aug 2002
ReviewSupport of respiratory failure in the pediatric surgical patient.
Severe respiratory failure in newborn and pediatric patients is associated with significant morbidity and mortality. Basic science laboratory investigation has led to advances in the understanding of ventilator-induced lung injury and in optimizing the supportive use of conventional ventilation strategies. ⋯ This review will focus on recent laboratory and clinical data regarding the techniques of lung protective ventilator strategies, inhaled nitric oxide, liquid ventilation, and extracorporeal life support (ECLS, ECMO). Some of these modalities are commonplace, while others may have much to offer the pediatric clinician if their benefit is clearly demonstrated in future clinical trials.