European journal of gastroenterology & hepatology
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Eur J Gastroenterol Hepatol · Mar 2016
Antibacterial gauzes are effective in preventing infections after percutaneous endoscopic gastrostomy placement: a retrospective analysis.
The most common complication after percutaneous endoscopic gastrostomy (PEG) placement is peristomal wound infection (up to 40% without antibiotic prophylaxis). Single-dose parenteral prophylactic antibiotics as advised by current guidelines decrease the infection rate to 9-15%. We assume a prolonged effect of local antibiotic treatment with antibacterial gauzes. This study is the first to describe the effect of antibacterial gauzes in preventing infections in PEG without the use of antibiotics. ⋯ Retrospectively, antibacterial gauzes are at least comparable with literature data on parenteral antibiotics in preventing peristomal wound infection after PEG placement, with an infection rate of 9.4%. Rates of other complications found in this study were comparable with current literature data.
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Eur J Gastroenterol Hepatol · Feb 2016
Multicenter StudyLong-term assessment of clinical response to adalimumab therapy in refractory ulcerative colitis.
The role of antitumour necrosis factor agents, in particular infliximab in ulcerative colitis (UC) has been well established. More recently adalimumab, a fully humanized antitumour necrosis factor α monoclonal antibody, was licensed for refractory moderately active UC in 2012. Available outcome data for adalimumab from routine clinical practice is limited. ⋯ Our study shows adalimumab is an effective and safe long-term therapy for moderately active UC refractory to other treatments. While this data is encouraging, further work is required on patient selection and to determine the impact of treatment on both natural history and quality of life.
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Eur J Gastroenterol Hepatol · Feb 2016
Observational StudyModel for end-stage liver disease score in the first 3 weeks after liver transplantation as a predictor for long-term outcome.
Early allograft dysfunction after liver transplantation (LTX) is not well defined. The aim of this study was to evaluate the value of early post-transplant model for end-stage liver disease (MELD) scores for predicting long-term outcome after transplantation. ⋯ In conclusion, early postoperative MELD scores predict outcome after LTX. The postoperative MELD score at POD14 is a good predictor for patient survival and at POD7 for the graft survival after LTX.
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Eur J Gastroenterol Hepatol · Jan 2016
Atlanta, revised Atlanta, and Determinant-based classification--application in a cohort of Portuguese patients with acute pancreatitis.
Acute pancreatitis (AP) represents a complex and potentially fatal disease with a highly variable clinical course. Three classification systems for assessing the severity in AP have been validated for clinical use. ⋯ Recent classifications proved to be more accurate in predicting important clinical outcomes in patients with AP.
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Eur J Gastroenterol Hepatol · Jan 2016
Peroral endoscopic full-thickness myotomy for the treatment of sigmoid-type achalasia: outcomes with a minimum follow-up of 12 months.
To explore the feasibility, safety, and efficacy of peroral endoscopic full-thickness myotomy (fPOEM) for the treatment of sigmoid-type achalasia. ⋯ fPOEM is feasible, safe, and effective for the treatment of sigmoid-type achalasia. A modified fPOEM may reduce the occurrence of gas-related complications. Yet, further experiences and long-term results are warranted.