European journal of gastroenterology & hepatology
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Eur J Gastroenterol Hepatol · Mar 2015
Clinical TrialEfficacy of real-time PCR-based detection of Helicobacter pylori infection and genotypic resistance-guided quadruple therapy as the first-line treatment for functional dyspepsia with Helicobacter pylori infection.
The eradication rate of Helicobacter pylori is steadily decreasing because of increasing resistance to clarithromycin. According to the new version of Maastricht IV guidelines, molecular tests can be performed as a substitute for bacterial culture and the standard clarithromycin susceptibility test for the detection of H. pylori and clarithromycin resistance directly on gastric biopsy samples. ⋯ Real-time PCR is efficacious for H. pylori detection and genotypic resistance-guided quadruple therapy has a high efficacy in treating functional dyspepsia with H. pylori infection.
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Eur J Gastroenterol Hepatol · Mar 2015
Comparative StudySarcopenia in liver cirrhosis: the role of computed tomography scan for the assessment of muscle mass compared with dual-energy X-ray absorptiometry and anthropometry.
Sarcopenia evaluated by computed tomography (CT) scan at the lumbar site has been identified as a risk factor for morbidity and mortality in cirrhosis. ⋯ CT scan can identify the highest percentage of sarcopenia in cirrhosis and no other techniques are actually available as a replacement. Future efforts should focus on approaches for assessing both skeletal muscle mass and function to provide a better evaluation of sarcopenia in cirrhotic patients.
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Eur J Gastroenterol Hepatol · Mar 2015
Endoscopic sedation and monitoring practices in Portugal: a nationwide web-based survey.
National surveys have been used to obtain information on sedation and monitoring practices in endoscopy in several countries. ⋯ The use of sedation is routine practice in colonoscopy, but not esophagogastroduodenoscopy. The preferred agent is propofol and it is used almost exclusively by anesthesiologists.
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Eur J Gastroenterol Hepatol · Feb 2015
Comparative StudyIntramucosal gastric cancer: the rate of lymph node metastasis in signet ring cell carcinoma is as low as that in well-differentiated adenocarcinoma.
Endoscopic resection (ER) plays a major role in the management of early gastric cancer. Less lymph node metastasis (LNM) and better survival rates were reported in early gastric signet ring cell carcinoma (SRC) than adenocarcinoma. We investigated and compared the clinicopathologic characteristics of endoscopic and surgical features in early gastric SRC and adenocarcinoma in accordance with histologic differentiation to examine the feasibility of ER in early gastric SRC. ⋯ Rate of LNM and submucosal invasion in early SRC was as low as those in early well-differentiated adenocarcinoma. ER for early gastric SRC may be an alternative to surgical gastrectomy under certain conditions.
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Eur J Gastroenterol Hepatol · Dec 2014
Comparative StudySustained participation, colonoscopy uptake and adenoma detection rates over two rounds of the Tallaght-Trinity College colorectal cancer screening programme with the faecal immunological test.
Studies to date support the use of the faecal immunological test (FIT) in colorectal cancer screening programmes, and it has been widely adopted across Europe, Canada, Australia, and the USA. Successive screening rounds are necessary to detect and prevent colorectal cancer. The overall success of FIT screening will depend on several factors, the most important probably being the acceptability of repeated screening rounds. Being a newer form of occult blood testing, there is little data available on its overall efficacy over time. ⋯ Repeated rounds of FIT screening in the Tallaght-Trinity College cohort achieved stable participation and neoplasia detection rates, suggesting that this mode of screening is both effective and acceptable to patients in the long term.