Clinical oncology : a journal of the Royal College of Radiologists
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Clin Oncol (R Coll Radiol) · Sep 2005
Meta AnalysisFactors influencing the use of single vs multiple fractions of palliative radiotherapy for bone metastases: a 5-year review.
Evidence from a number of randomised trials and meta-analyses supports the use of single-fraction radiotherapy for the palliation of painful bone metastases. This study explores patient and treatment factors that influence the choice of single compared with multiple-fraction radiotherapy for the treatment of bone metastases in clinical practice. ⋯ One-third of palliative radiotherapy courses for bone metastases in our programme were given as single fractions. Performance status, age and anatomical site were significant factors affecting single compared with multiple fractionation. The variation in the use of single fractions over time may reflect the dynamic process of interpretation and application of evidence from clinical trials to practice.
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Clin Oncol (R Coll Radiol) · Dec 2004
Case ReportsNeutropenia occurring after starting gabapentin for neuropathic pain.
We report a case of neutropenia occurring in a patient receiving gabapentin for neuropathic pain. Five weeks after treatment started, the patient was admitted to hospital with neutropenic sepsis. Gabapentin is widely used, and neutropenia is a rare adverse effect. This case highlights a serious and potential life-threatening complication.