The British journal of dermatology
-
Randomized Controlled Trial Multicenter Study Comparative Study
Photodynamic therapy vs. topical imiquimod for treatment of superficial basal cell carcinoma: a subgroup analysis within a noninferiority randomized controlled trial.
A recent noninferiority randomized controlled trial (RCT) indicated that imiquimod can be considered as superior to methylaminolevulinate photodynamic therapy (MAL-PDT) in the treatment of superficial basal cell carcinoma (sBCC). Knowledge of treatment effectiveness in subgroups of patients is of great value in clinical practice to select the most effective treatment for an individual patient with sBCC. ⋯ Imiquimod remains the first-choice treatment for sBCC in terms of effectiveness. In older patients with sBCC on the lower extremities MAL-PDT might be preferred. Results should be interpreted carefully as subgroup analyses were exploratory and not driven by prior hypotheses.
-
Letter Multicenter Study Comparative Study
A U.K. multicentre audit of the assessment and management of psoriasis in children.
-
Review Meta Analysis Comparative Study
Comparative efficacy of biological treatments for moderate-to-severe psoriasis: a network meta-analysis adjusting for cross-trial differences in reference arm response.
Multiple biological therapies are approved for the treatment of moderate-to-severe psoriasis. ⋯ A model adjusted for reference arm response rates was found to fit clinical trial data significantly better than unadjusted models.