European journal of internal medicine
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Eur. J. Intern. Med. · Dec 2021
A metabolomic index based on lipoprotein subfractions and branched chain amino acids is associated with incident hypertension.
The present study aims to evaluate the performance of the Diabetes Risk Index (DRI), a metabolomic index based on lipoprotein particles and branched chain amino acids, on the incidence of newly developed hypertension in a large community dwelling cohort. ⋯ Higher DRI scores were associated with an increased risk of incident hypertension. Such association was independent of traditional clinical risk factors for hypertension.
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Eur. J. Intern. Med. · Dec 2021
Multidisciplinary team led by internists improves diabetic foot ulceration outcomes a before-after retrospective study.
Diabetic foot ulceration (DFU) is associated with high mortality and morbidity. A multidisciplinary approach has been suggested, but as these patients usually present with various comorbidities, leadership of a multidisciplinary team by internists was initiated. Our aim was to evaluate the impact of the leadership of the multidisciplinary team by internists on the outcomes of patients with DFU. ⋯ The treatment of hospitalized DFU patients by a multidisciplinary team led by internists using a holistic therapeutic approach demonstrated improved clinical outcomes.
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Eur. J. Intern. Med. · Dec 2021
Outcomes of patients with heart failure with preserved ejection fraction discharged on treatment with neurohormonal antagonists after an episode of decompensation.
To analyze the frequency with which patients with heart failure with preserved ejection fraction (HFpEF) discharged after an acute heart failure (AHF) episode are treated with antineurohormonal drugs (ANHD), the variables related to ANHD prescription and their relationship with outcomes. ⋯ 70% of HFpEF patients are discharged with ANHD after an AHF episode. ANHD do not seem to reduce mortality or adverse events in HFpEF patients, only RAASi could provide some benefits, reducing the risk of hospitalization for AHF.
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Eur. J. Intern. Med. · Dec 2021
The role of minor salivary glands' biopsy in the diagnosis of Sjögren's syndrome and other systemic diseases.
The minor salivary glands' biopsy is a minimally invasive procedure used for the diagnosis of Sjögren's syndrome. Its significance has also been reported in other inflammatory/infiltrative diseases. The objectives are to investigate its use in the diagnosis of Sjögren's syndrome, as well as to evaluate its role in the diagnosis of amyloidosis and sarcoidosis. ⋯ The minor salivary glands' biopsy is a simple procedure with effectiveness in the diagnosis of Sjögren's syndrome and amyloidosis. In this study, its use increased the number of patients who met the Sjögren's syndrome classification criteria. It also appears to be useful in the diagnosis of amyloidosis.
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Doctors are often asked to make input into bed calculations but are often not provided with the necessary background to the potential flaws in such calculations. A simple method is presented which allows both inter- and intra-national comparison of bed numbers which are sensitive to both population age structure and the role of nearness-to-death in medical bed demand. Local adjustment will be required to account for the additional demand arising for hospitals servicing more deprived populations.