European journal of internal medicine
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Eur. J. Intern. Med. · Feb 2022
EditorialPulmonary embolism - An EFIM guideline critical appraisal and adaptation for practicing clinicians.
Several trials have been conducted in the last decades that challenged the management of patients with acute pulmonary embolism (PE) in terms of diagnosis and treatment. Updated international clinical practice guidelines (CPGs) endorsed the evidence from these trials. The aim of this document was to adapt recommendations from existing CPGs to assist physicians in decision making concerning specific and complex scenarios related to acute PE. ⋯ By the use of proper methodology for the adaptation process, this document offers a simple and updated guide for practicing clinicians dealing with complex patients.
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Eur. J. Intern. Med. · Feb 2022
Hematuria and subsequent long-term risk of end-stage kidney disease: A Danish population-based cohort study.
Hematuria is a frequent incidental clinical finding and may be a symptom of pre-existing underlying benign or malignant urinary tract or kidney disease. However, in patients with no apparent underlying cause of hematuria, long-term prognosis of hematuria remains unknown. ⋯ A hospital-based hematuria diagnosis in patients with no apparent underlying cause of hematuria is a marker of an increased risk of future ESKD.
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Eur. J. Intern. Med. · Feb 2022
Off-label use of biologics for the treatment of refractory and/or relapsing granulomatosis with polyangiitis.
To describe the efficacy and safety of off-label use of biologics for refractory and/or relapsing granulomatosis with polyangiitis (GPA). ⋯ This real-life study suggests that off-label use of anti-TNF-α and abatacept shows efficacy in less than 50% of refractory and/or relapsing GPA.