European journal of internal medicine
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Eur. J. Intern. Med. · May 2023
Temporal relationship between hyperuricemia and hypertension and its impact on future risk of cardiovascular disease.
Although hyperuricemia and hypertension are significantly correlated, their temporal relationship and whether this relationship is associated with risk of cardiovascular disease (CVD) are largely unknown. This study aimed to examine temporal relationship between hyperuricemia and hypertension, and its association with future risk of CVD. ⋯ Increased SUA levels probably precede elevated BP, and BP partially mediates the pathway from SUA to incident CVD.