European journal of internal medicine
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Eur. J. Intern. Med. · Jul 2023
Meta AnalysisA systematic review and meta-analysis of all sham and placebo controlled trials for resistant hypertension.
There is a lack of consensus regarding the best add on therapy for treatment of resistant hypertension (RH). This is likely secondary to a paucity of data on the comparative effectiveness of proposed therapies for RH. ⋯ MRA lowers BP in patients with RH more than RD, which seems to have little to no effect in RH. ERAs lead to a statistically significant reduction in BP but the confidence in efficacy is limited due to the low number of studies and differences in trial population. Individual factors and their impact on treatment response in RH should be investigated in future research.