European journal of internal medicine
-
Eur. J. Intern. Med. · Nov 2024
Meta AnalysisDoor-to-antibiotic time and mortality in patients with sepsis: Systematic review and meta-analysis.
To evaluate whether the timing of initial antibiotic administration in patients with sepsis in hospital affects mortality. ⋯ Our findings show an improvement in mortality in sepsis patients with early administration of antibiotics at <3 and <6 hrs. Thus, these results suggest that antibiotics should be administered within 3 hrs of sepsis recognition or ED arrival regardless of the presence or absence of shock.
-
Eur. J. Intern. Med. · Nov 2024
Multicenter StudyAssociations of cannabis use and body mass index-The Coronary Artery Risk Development in Young Adults (CARDIA) study.
With increasing use of cannabis, we need to know if cannabis use and Body Mass Index (BMI) are associated. ⋯ Current cannabis use was associated with lower BMI, but cumulative cannabis use and cessation were not. This suggests that recreational cannabis use may not lead to clinically relevant changes in BMI and that the association between current cannabis use and lower BMI is likely due to residual confounding.
-
Obesity presents a significant public health challenge, with a growing prevalence among older adults and addressing obesity in older adults presents unique challenges. Behaviour therapy is a cornerstone in obesity management, yet its application in older populations, is underexplored. This narrative review, based on the current literature, examines the role of behavioural change techniques (BCTs) in addressing obesity in older adults, highlighting the need for tailored interventions that consider age-related challenges. ⋯ Therefore, the design and implementation of BCTs in this population require careful evaluation and customization. Tailored interventions that consider the unique needs of this population, such as preserving muscle mass and addressing functional limitations, are essential. Future research should focus on large-scale, well-designed trials to elucidate the optimal BCTs for older individuals, ensuring interventions are diverse and inclusive to meet the needs of older adults with obesity.