The British journal of general practice : the journal of the Royal College of General Practitioners
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Randomized Controlled Trial
Influence of polypharmacy on patients with heart failure with preserved ejection fraction: a retrospective analysis on adverse outcomes in the TOPCAT trial.
Polypharmacy is common in heart failure (HF), whereas its effect on adverse outcomes in patients with HF with preserved ejection fraction (HFpEF) is unclear. ⋯ A high prevalence of high medication burden at baseline was reported in patients with HFpEF. The high medication burden might increase the risk of hospital readmission, but not the mortality.
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Randomized Controlled Trial
Matching depression management to severity prognosis in primary care: results of the Target-D randomised controlled trial.
Mental health treatment rates are increasing, but the burden of disease has not reduced. Tools to support efficient resource distribution are required. ⋯ Matching management to prognosis using a person-centred e-health platform improves depressive symptoms at 3 months compared to usual care and could feasibly be implemented at scale. Scope exists to enhance the uptake of management options.