The British journal of general practice : the journal of the Royal College of General Practitioners
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On 8 December 2020 NHS England administered the first COVID-19 vaccination. ⋯ The NHS rapidly delivered mass vaccination. In this study a data-monitoring framework was deployed using publicly auditable methods and a secure in situ processing model, using linked but pseudonymised patient-level NHS data for 57.9 million patients. Targeted activity may be needed to address lower vaccination coverage observed among certain key groups.