Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Apr 1992
Randomized Controlled Trial Comparative Study Clinical TrialSedation for bronchofiberoscopy: comparison between propofol infusion and intravenous boluses of fentanyl and diazepam.
Two methods of sedation were evaluated in unpremedicated patients undergoing elective bronchofiberoscopy. The patients were randomly allocated to receive either propofol infusion 1 mg kg-1 h-1 preceded by a 1 mg kg-1 bolus (15 patients) (the propofol group) or intravenous fentanyl 1 micrograms kg-1 and diazepam 0.05 mg kg-1 (15 patients) (the fentanyl+diazepam group). Thirteen patients were treated twice during the study period and sedated with both methods (the first treatment according to random order and the second with the method not used on the first occasion). ⋯ The decrease was statistically significant in both groups (P less than 0.001). After sedation, systolic arterial pressures (SAP) decreased in both groups (P less than 0.01). Compared to values immediately before starting bronchofiberoscopy, SAP increased during the procedure in both groups (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
-
Acta Anaesthesiol Scand · Apr 1992
Randomized Controlled Trial Clinical TrialThe influence of naloxone infusion on the action of intrathecal diamorphine: low-dose naloxone and neuroendocrine responses.
The influence of an intravenous infusion of naloxone 1 microgram kg-1 h-1, in combination with intrathecal diamorphine, on analgesia and hormonal stress responses after laminectomy was assessed in a blinded, randomized, placebo-controlled study. Twenty-seven patients undergoing laminectomy with postoperative analgesia provided by intrathecal diamorphine were investigated. ⋯ The postoperative concentrations of both blood glucose and serum cortisol were reduced in the naloxone group compared to the control group (P less than 0.05). These results may indicate an excitatory role for the hypothalamic mu receptor in hypothalamo-pituitary-adrenocortical axis regulation.
-
Acta Anaesthesiol Scand · Apr 1992
Randomized Controlled Trial Comparative Study Clinical TrialPsychomotor recovery following propofol or isoflurane anaesthesia for day-care surgery.
A newly developed test for the assessment of psychomotor recovery--the perceptive accuracy test (PAT)--is described. Seventy-four subjects who performed the test though that it was easy to perform and some were motivated to try it on a number of occasions. Eight persons performed the test on different days and at different periods of time; the results were consistent and reproducible. ⋯ There was a significant difference (P less than 0.01) in psychomotor recovery on the PAT-200 between the propofol group and control groups, but not in the isoflurane and control groups at 30 min. Both groups had returned to baseline values at 60 min in the PAT-60 and PAT-200. The choice reaction time showed no significant difference in either group 30 min after the anaesthetic.(ABSTRACT TRUNCATED AT 250 WORDS)
-
Acta Anaesthesiol Scand · Apr 1992
Randomized Controlled Trial Comparative Study Clinical TrialProphylactic diclofenac infusions in major orthopedic surgery: effects on analgesia and acute phase proteins.
The influence of diclofenac, given by continuous i.v. infusion starting preoperatively, on postoperative pain and inflammation was assessed in a double-blind, randomized, placebo-controlled study in 40 patients scheduled for major orthopedic surgery. Starting 30 min before induction the patients received either diclofenac (0.35 mg.kg-1 bolus followed by a constant-rate infusion of 90 micrograms.min-1) or placebo for 24 h. ⋯ The diclofenac treatment had no influence on hematological and coagulation profiles, nor on muscle and liver enzymes in comparison with placebo. Both patients and observer rated the diclofenac treatment as significantly superior to the placebo treatment.
-
Acta Anaesthesiol Scand · Apr 1992
Randomized Controlled Trial Comparative Study Clinical TrialTotal intravenous anaesthesia for direct laryngoscopy: propofol infusion compared to thiopentone combined with midazolam and methohexitone infusion.
Total intravenous anaesthesia for direct laryngoscopy was investigated in 40 patients, randomized into four groups of 10 patients each. First, propofol infusion was compared to thiopentone combined with midazolam. Next, a comparison of propofol infusion with methohexitone infusion was undertaken. ⋯ Completeness of recovery, assessed by means of a coin counting test, was faster in the propofol group compared to the thiopentone/midazolam group, while no difference could be demonstrated between the second propofol group and the methohexitone group. It is concluded that propofol seems to be superior to both thiopentone/midazolam and methohexitone with respect to the stability of peroperative blood pressure. Concerning recovery, propofol is superior to thiopentone/midazolam, but offers no advantage over methohexitone.