Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 1994
Randomized Controlled Trial Clinical TrialIbuprofen in the treatment of postoperative pain in small children. A randomized double-blind-placebo controlled parallel group study.
The efficacy of ibuprofen as a pre-emptive analgesic for postoperative pain was investigated in 81 children in the age between one and four years subjected to elective surgery. The patients were randomized into two groups receiving rectally either ibuprofen 40 mg.kg-1.d-1, divided into four equal doses, or placebo in a double blind manner. Additional pain relief was provided by morphine. ⋯ Heart rate and arterial blood pressure were lower in children who received ibuprofen, probably reflecting better analgesia. The side effects were mild and similar in both groups. We conclude that rectal ibuprofen is a safe analgesic in children in the age between 1 and 4 years and reduces the need of opioids for postoperative pain relief.
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Acta Anaesthesiol Scand · Jul 1994
Use of 29-gauge spinal needles and a fixation device with combined spinal epidural technique.
One hundred patients between 15-46 years, undergoing elective surgery, were given spinal anaesthesia using 29-gauge spinal needles introduced through a Tuohy needle with a fixation device. Successful spinal anaesthesia was achieved in 98%. A success rate of 100% was achieved when a combined spinal epidural technique was used. Ninety-eight percent of the patients would prefer the same anaesthesia procedure for similar kind of surgery in the future.
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Acta Anaesthesiol Scand · Jul 1994
Editorial Comment Historical ArticleThe polio epidemic in Copenhagen in 1952--and how the anaesthetist came out of the operating room.
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Acta Anaesthesiol Scand · Jul 1994
Randomized Controlled Trial Clinical Trial Retracted PublicationInfluence of volume replacement with different HES-solutions on microcirculatory blood flow in cardiac surgery.
A variety of hydroxyethyl starch HES preparations with different molecular weight average (Mw) and molar substitution (MS) is available for volume replacement during acute normovolemic haemodilution (ANH). Particularly with regard to microcirculation, the ideal solution for volume therapy has not been found. The influence of four different HES preparations on macro- and microcirculation was investigated in 40 patients scheduled for elective aorto-coronary bypass grafting and undergoing ANH (preoperative withdrawn blood: 10 ml.kg-1): 1) 6% HES with Mw of 450,000 dalton and MS of 0.7; 2) 6% HES with Mw of 200,000 dalton and MS of 0.5; 3) 6% HES with Mw of 200,000 dalton and MS of 0.62; 4) 6% HES with Mw of 40,000 dalton and MS of 0.5. ⋯ After ANH, skin capillary blood flow measured at the forehead decreased in all patients except in patients of group 2 (200/0.5: max. +18%). Group 3 (200/0.62) showed the highest decrease in forehead-LDF. During CPB, forehead-LDF decreased significantly in groups 3 (200/0.62) and 4 (40/0.5).(ABSTRACT TRUNCATED AT 250 WORDS)