Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Nov 1995
Hyperkalaemia associated with haemorrhagic shock in rabbits: modification by succinylcholine, vecuronium and blood transfusion.
In haemorrhagic patients, hyperkalaemia may occur after succinylcholine administration. We investigated in haemorrhagic rabbits whether vecuronium caused hyperkalaemia and if blood transfusion prevented succinylcholine-induced hyperkalaemia. Rabbits were lightly anaesthetized with halothane/N2O and 30-35 ml/kg blood were withdrawn to cause arterial pH to decrease to approximately 7.0-7.1. ⋯ The K+ increase at 5 min for Group S (1.8 +/- 0.8) was significantly higher than those for Group C (1.0 +/- 0.6) or Group V (0.9 +/- 0.4), but was not different from that of Group T (1.5 +/- 0.7). We conclude that haemorrhage and succinylcholine cause hyperkalaemia in rabbits. Muscle relaxation itself does not appear to be a factor, but transfusion may lessen the hyperkalaemia.
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Acta Anaesthesiol Scand · Nov 1995
Resistance to atracurium in rats with experimental inflammation: role of protein binding.
The influence of altered protein binding on the neuromuscular effect of atracurium has been studied in rats with experimental inflammation induced by subcutaneous injection of turpentine oil. Doses of atracurium ranging from 0.45 to 1.5 mg.kg-1 were administered to control (n = 30) and to experimental inflammation induced rats (n = 30). Neuromuscular transmission was monitored by recording the twitch tension of the tibialis-anterior muscle elicited by stimulation of the sciatic nerve. ⋯ For equipotent doses ED95 (defined as the effective dose eliciting 95% of maximum effect), no differences were found in recovery time and duration of action between the two groups of rats. Mucoproteins levels (index of alpha 1-acid glycoprotein (AAG) and protein binding were significantly increased in rats with experimental inflammation as compared to control rats. Based on these results, altered serum protein binding of atracurium appears to be responsible, at least in part, for the resistance to atracurium.
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Acta Anaesthesiol Scand · Nov 1995
Editorial CommentTime for revivification of paravertebral blocks?
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Acta Anaesthesiol Scand · Nov 1995
Randomized Controlled Trial Clinical TrialEffects of ephedrine on oxygen consumption and cardiac output.
Bolus doses of ephedrine are often used by anaesthesiologists for intraoperative hypotension. This randomized single-blind cross-over study was designed to simultaneously evaluate circulatory, respiratory and metabolic effects of intravenously given ephedrine in 12 healthy male volunteers. Oxygen uptake and carbon dioxide excretion were measured with indirect calorimetry and non-invasive transthoracic electrical bioimpedance was used for cardiac output measurements. ⋯ There were no significant changes in the quotient between oxygen uptake rate and cardiac index, VO2/CI during the 30 min study period. The O2 saturation was not altered. The present study indicates that ephedrine increases oxygen demand and supply in a similar magnitude.
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Acta Anaesthesiol Scand · Nov 1995
Randomized Controlled Trial Comparative Study Clinical TrialComparison of propofol and increased doses of thiopentone for laryngeal mask insertion.
Conditions for insertion of the laryngeal mask were assessed following induction of anaesthesia with either propofol 2.5 mg/kg, thiopentone 5.0 mg/kg or thiopentone 6.0 mg/kg in 120 patients premedicated with diazepam 10 mg. Insertion following induction with thiopentone 5.0 mg/kg and 6.0 mg/kg resulted in a greater incidence of gagging (P < 0.001 and P < 0.05, respectively) compared with propofol 2.5 mg/kg.