Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Sep 1996
Pharmacokinetics of piritramide after an intravenous bolus in surgical patients.
Piritramide is a synthetic opioid analgesic which is commonly used for postoperative analgesia. It is structurally related to meperidine, exhibiting full mu-receptor agonism. Pharmacokinetic data of the drug have not been reported so far. ⋯ Since the elimination half-life of piritramide appears to exceed the duration of clinically effective analgesia observed during the treatment of acute pain, the dose of piritramide should be titrated carefully during long-term treatment to avoid accumulation that may lead to adverse effects.
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Acta Anaesthesiol Scand · Sep 1996
Randomized Controlled Trial Clinical TrialThe combination of morphine with local anaesthetic in rhinoplasty--no evidence of a peripheral morphine effect.
The recognition of a peripheral opioid action has prompted a number of clinical reports demonstrating a prolonged analgesic effect of peripheral opiate. As most studies have used a model of intraarticular instillation of narcotic we examined direct morphine infiltration of the surgical site in a unique clinical model. ⋯ The results of this study indicate that the preoperative injection of intrawound morphine in combination with the local anesthetic both promotes bleeding and has an early pain-enhancing effect while providing no late analgesic benefit beyond that of IM morphine.
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Acta Anaesthesiol Scand · Sep 1996
Randomized Controlled Trial Clinical TrialIs sufentanil a useful opioid for laryngomicroscopy?
Alfentanil is commonly used as opioid analgesic for short surgical procedures. Little is known about the usefulness of sufentanil for this purpose. We investigated the effects of alfentanil and sufentanil on haemodynamic characteristics, catecholamine levels, and adrenocorticotropic hormone (ACTH) and cortisol contents during elective laryngomicroscopy and short laryngeal surgery (LM). ⋯ Clinical recovery is achieved most rapidly with alfentanil in ultra short surgical procedures. However, if surgery is expected to be longer than about 12 min also sufentanil at a dose of 0.25 micrograms/kg seems to be useful for this kind of surgery.
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Abstention from food and drink prior to anaesthesia remains a cornerstone in safe practice. Despite the lack of scientific support, previous guidelines, similar for fluids and solids, have for more than three decades more often than not recommended "nil by mouth" ("nothing-per-os"; "NPO" in the US) after midnight or a fixed duration of time. ⋯ Since there may be a discrepancy between conclusions based on scientific studies and the current routine practice-this presentation is intended to survey the current recommendations in different countries and how they relate to publications on the subject. Opinions are mainly derived from officers of associations linked to The World Federation for Anaesthesiologists (WFSA) and from current literature.
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Acta Anaesthesiol Scand · Sep 1996
Influence of body compartments on propofol induction dose in female patients.
For induction of anaesthesia, drugs such as propofol are commonly administered according to a per weight basis. However, drugs are primarily distributed to the fat-free mass. This study was undertaken to determine the relationship between propofol requirement for induction and body mass determined by bioimpedance analysis (BIA) or by body mass index (BMI). ⋯ Our results indicate that propofol requirements for induction are proportional to the lean body mass rather than total body weight.