Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 1997
Randomized Controlled Trial Clinical TrialPreoperative infiltration of bupivacaine--effects on pain relief and trauma response (cortisol and interleukin-6).
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Acta Anaesthesiol Scand · Apr 1997
Magnesium--a profibrillatory or antifibrillatory drug depending on plasma concentration, heart rate and myocardial perfusion.
The opinions on the efficacy of magnesium as an antiarrhythmic drug vary considerably. The action of magnesium on vulnerability to fibrillation was therefore investigated in anaesthetized, open-chest pigs under different conditions as regards plasma concentration, heart rate and myocardial perfusion. ⋯ Magnesium may develop profibrillatory or antifibrillatory effects depending on plasma concentration, heart rate and myocardial perfusion.
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Acta Anaesthesiol Scand · Apr 1997
Analysis of anaesthesia in patients suspected to be susceptible to malignant hyperthermia before diagnostic in vitro contracture test.
It is well known that patients susceptible to malignant hyperthermia (MH) do not always develop clinical signs of MH at their first anaesthetic. Large material concerning this epidemiological problem do not exist. Therefore, we undertook the present investigation at the Danish Malignant Hyperthermia Register. ⋯ The clinical expressivity of the MHS phenotype was found to be 34%-54%.
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Acta Anaesthesiol Scand · Apr 1997
Randomized Controlled Trial Clinical TrialNitrous oxide has different effects on the EEG and somatosensory evoked potentials during isoflurane anaesthesia in patients.
Electroencephalogram (EEG) and somatosensory evoked potentials (SEPs) are altered by inhalation anaesthesia. Nitrous oxide is commonly used in combination with volatile anaesthetics. We have studied the effects of nitrous oxide on both EEG and SEPs simultaneously during isoflurane burst-suppression anaesthesia. ⋯ The results suggest that during isoflurane anaesthesia, nitrous oxide has a different effect on EEG and cortical SEP at the same time. The effects of nitrous oxide may be mediated by cortical and subcortical generators.
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Acta Anaesthesiol Scand · Apr 1997
Randomized Controlled Trial Clinical TrialThe haemodynamic effects of rocuronium and vecuronium are different under balanced anaesthesia.
Rocuronium has been reported to have minimal haemodynamic effects. However, this conclusion has been drawn primarily from investigations conducted under narcotic-based anaesthesia. This study was designed to evaluate the cardiovascular effects of rocuronium under isoflurane/N2O/fentanyl anaesthesia and to compare rocuronium's haemodynamic effects to those of vecuronium and pancuronium. ⋯ The haemodynamic effects of rocuronium and vecuronium are different under balanced anaesthesia. Rocuronium may attenuate the fall in MAP that often occurs under balanced anaesthesia without surgical stimulation.