Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 1998
Randomized Controlled Trial Clinical TrialThe inflammatory cytokine response after autotransfusion of shed mediastinal blood.
The inflammatory response in patients undergoing cardiac surgery with cardiopulmonary bypass is well known and increased levels of inflammatory cytokines have been shown. High levels of cytokines have been reported in blood drained from the surgical field. The present study aimed to elucidate whether autotransfusion of shed mediastinal blood in itself causes increased cytokine levels in coronary artery bypass graft (CABG) patients. ⋯ Shed mediastinal blood contains high levels of IL-6. However, autotransfusion of shed mediastinal does not cause measurable elevations in plasma levels of IL-6. In vitro study shows that autotransfusion activates leucocytes, which may enhance production of inflammatory cytokines.
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Acta Anaesthesiol Scand · May 1998
Case ReportsEffect of an endotoxin-removing column containing immobilized polymyxin B fiber in a patient with septic shock from gram-positive infection.
A 67-yr-old patient with septic shock caused by gram-positive infection fell into circulatory collapse. Direct hemoperfusion with an endotoxin-removing column was then carried out for 120 min. ⋯ After this treatment, the patient recovered. From this experience, we consider that the endotoxin-removing column may be effective for septic shock patients.