Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Sep 1998
Meta AnalysisEpidural fentanyl, adrenaline and clonidine as adjuvants to local anaesthetics for surgical analgesia: meta-analyses of analgesia and side-effects.
The risk/benefit ratio of adding fentanyl, adrenaline and clonidine to epidural local anaesthetics for improving intraoperative analgesia is unclear. This meta-analysis was performed to clarify this issue. ⋯ The analysis of current literature shows that the addition of fentanyl to local anaesthetics for intraoperative epidural analgesia is safe and advantageous. The reduction in the incidence of pain during surgery is quantitatively high and therefore clinically significant. Side-effects are mild. Randomized, controlled trials have to be performed in order to clarify the role of adrenaline and clonidine as epidural adjuvants for surgical analgesia.
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Acta Anaesthesiol Scand · Sep 1998
Randomized Controlled Trial Comparative Study Clinical TrialPrevention of nausea and vomiting with granisetron, droperidol and metoclopramide during and after spinal anaesthesia for caesarean section: a randomized, double-blind, placebo-controlled trial.
Nausea and vomiting during and after spinal anaesthesia for caesarean section are distressing to the patient. This study was undertaken to evaluate the efficacy and safety of granisetron, droperidol and metoclopramide for the prevention of nausea and vomiting in parturients undergoing caesarean section under spinal anaesthesia. ⋯ Granisetron is highly effective for preventing nausea and vomiting during and after spinal anaesthesia for caesarean section. Droperidol and metoclopramide are effective for the prevention of intraoperative, post-delivery emesis, but are ineffective for the reduction of the incidence of postoperative emesis.
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Acta Anaesthesiol Scand · Sep 1998
The influence of age and administration rate on the brain sensitivity to propofol in rats.
It is well established that the dose of propofol for induction of anaesthesia is influenced by patient age. This may be explained by differences in pharmacokinetics or pharmacodynamics. To evaluate the effect of age on propofol pharmacodynamics, the brain concentration of propofol at the time of an EEG end-point was used as a measure of CNS sensitivity. ⋯ The dose of propofol for induction of anaesthesia in rats is influenced by animal age and administration rate. Young animals need a larger induction dose than old rats, but are more sensitive as measured by the brain concentration of propofol. The larger induction dose in young rats when compared with adults is explained by pharmacokinetic differences rather than by pharmacodynamic changes.