Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · May 1999
Interaction between fluconazole and midazolam in intensive care patients.
Midazolam is used for sedation of intensive care unit (ICU) patients and it is extensively metabolised by CYP3A4 enzymes. The antimycotic fluconazole is often used in these patients as well and has been shown to inhibit CYP3A4-mediated drug metabolism. ⋯ In ICU patients receiving fluconazole, reduction of midazolam infusion rate should be considered if the degree of sedation is found to be increasing.
-
Acta Anaesthesiol Scand · May 1999
Comparative StudyPreoperative anxiety is associated with a high incidence of problematic behavior on emergence after halothane anesthesia in boys.
In our clinical experience, children who are crying before anesthesia are more likely to show agitated behavior on emergence. ⋯ The boys who were anxious before anesthesia showed a significantly greater incidence of problematic behavior on emergence from halothane anesthesia, compared with the boys who were calm before anesthesia.
-
Acta Anaesthesiol Scand · May 1999
Randomized Controlled Trial Comparative Study Clinical TrialEnhancement of intrathecal lidocaine by addition of local and systemic clonidine.
Enhancement of local anesthetic-produced regional blocks by clonidine seems well established. There are insufficient data about dose-effect relationship of combinations of clonidine with individual agents, efficiency of local versus systemic administration of clonidine, and comparative evaluation of clonidine with vasoconstrictors. Because of unavailability of long-acting local anaesthetics at the time of study, our aim was to evaluate augmentation of lidocaine spinal block with local or systemic clonidine and to compare the results with the efficacy of intrathecal phenylephrine. ⋯ Our results indicate that addition of clonidine to lidocaine, irrespective of the route of administration, prolongs the duration of spinal block and permits a reduction of the lidocaine dose needed for a given duration of block. Addition of phenylephrine results in a less pronounced statistically significant prolongation of anaesthesia. The regression of sensory block before restoration of motor function seems to be a specific (and unfortunate) effect of both clonidine and phenylephrine.
-
Acta Anaesthesiol Scand · May 1999
Randomized Controlled Trial Clinical TrialSevoflurane causes more postoperative agitation in children than does halothane.
An agitated recovery may occur after inhalation anesthesia. The aim of the present study was to assess the recovery quality after mask anesthesia with either halothane or sevoflurane in children. ⋯ Early postanesthetic agitation and recovery was faster after mask anesthesia with sevoflurane than after halothane. There was a higher incidence of agitation in younger children, without correlation to pain.
-
Acta Anaesthesiol Scand · May 1999
Do blood levels of neuron-specific enolase and S-100 protein reflect cognitive dysfunction after coronary artery bypass?
Neuron-specific enolase (NSE) and S-100 protein have been used as markers for major brain damage. Cognitive dysfunction after cardiac surgery represents subtle brain damage that is detected by neuropsychological testing. We hypothesised that blood levels of NSE and S-100 protein would increase after coronary artery bypass surgery and that the change in blood level would correlate with the change in cognitive function. ⋯ NSE seems to be a useful blood marker for early cognitive dysfunction after coronary artery bypass surgery.