Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Aug 2009
Case ReportsExtremely prolonged neuromuscular blockade after rocuronium: a case report.
It is known that the duration of rocuronium action can be prolonged in elderly patients and that such action shows important interindividual variability. We report a case of prolonged neuromuscular block lasting 11 h, in a woman subjected to kidney transplantation. The possible causes of such prolonged action, inherent to the drug, or related to external factors, are commented.
-
Acta Anaesthesiol Scand · Aug 2009
Prospective evaluation of the time to peak effect of propofol to target the effect site in children.
The plasma-effect site equilibration rate constant (k(e0)) of propofol has been determined in children with the use of the time to maximum effect (t(peak)), however, it has not been validated. The objective was to measure the t(peak;) of propofol with two depths of anesthesia monitors in children and to evaluate these measurements with a target-controlled infusion (TCI) system. ⋯ The small delay between the evolution of Ce of propofol and the observed effect suggests that this can be a useful model to target the effect site in children.
-
Acta Anaesthesiol Scand · Aug 2009
Multicenter Study Clinical TrialThe incidence of intra-operative awareness during general anesthesia in China: a multi-center observational study.
The incidence of awareness in patients undergoing general anesthesia is 0.1-0.2% in Western countries. The medical literatures about awareness during general anesthesia are still rare in China, but some previous studies have reported a higher incidence (1.4-6%) of intra-operative awareness. To find out the reason why the incidence reported in China is much higher than that in Western countries, we performed a prospective, multicenter, non-randomized observational study to determine the true incidence of intra-operative awareness in China. ⋯ The incidence of intra-operative awareness in China is approximately 0.41%, two to three times higher than that widely cited in Western countries. Inappropriately light anesthesia, and the population proportion of surgery and general anesthesia in China may account for the difference. (ClinicalTrials.gov Identifier, NCT00693875.).
-
Acta Anaesthesiol Scand · Aug 2009
Randomized Controlled TrialKetamine attenuates post-operative cognitive dysfunction after cardiac surgery.
Post-operative cognitive dysfunction (POCD) commonly occurs after cardiac surgery. Ketamine exerts neuroprotective effects after cerebral ischemia by anti-excitotoxic and anti-inflammatory mechanisms. We hypothesized that ketamine attenuates POCD in patients undergoing cardiac surgery concomitant with an anti-inflammatory effect. ⋯ Ketamine attenuates POCD 1 week after cardiac surgery and this effect may be related to the anti-inflammatory action of the drug.
-
Acta Anaesthesiol Scand · Aug 2009
Randomized Controlled Trial Comparative StudyA new supraglottic airway device: LMA-supreme, comparison with LMA-Proseal.
The LMA-Supreme() (S-LMA()) is a new supraglottic airway device that presents combined features of flexibility, curved structure and single use and a different cuff structure. The purpose of this study was to compare the oropharyngeal leak pressures (OLP) of LMA-Proseal() (P-LMA()) and S-LMA(). ⋯ Our findings suggest that S-LMA() had leak pressures similar to the P-LMA(), and this new airway device proved to be successful during both spontaneous and positive pressure ventilation.