Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Mar 2013
Sevoflurane induces short-term changes in proteins in the cerebral cortices of developing rats.
Exposure to intravenous or inhaled anesthetic agents has potential deleterious effects on the developing brain. However, the mechanisms are not clear. Herein, we investigated protein expression changes in neonatal rat brains after exposure to sevoflurane, an inhalational anesthetic commonly used for pediatric patients. ⋯ These findings suggest that sevoflurane may cause short-term neuronal apoptosis and disturbances of neuronal migration, differentiation and energy metabolism in neonatal rat brains, and that these disturbances may contribute to its neurodegenerative effects.