Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2015
A novel concept for continuous peripheral nerve blocks. Presentation of a new ultrasound-guided device.
Existing techniques for placing and maintaining the position of peripheral nerve catheters are associated with variable success rates and frequent secondary failures. These factors may affect the clinical efficacy and usefulness of peripheral nerve catheters. ⋯ Preliminary proof of concept of this novel method demonstrates that precise in-plane ultrasound-guided initial placement and secondary in-plane readjustment is possible in fresh cadavers. Future studies should address the clinical efficacy and usefulness of this novel concept.
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Acta Anaesthesiol Scand · Feb 2015
Meta AnalysisEfficacy and safety of pregabalin for treating painful diabetic peripheral neuropathy: a meta-analysis.
Pregabalin is considered to be an effective treatment for painful diabetic peripheral neuropathy (DPN), but controversy exists about its efficacy and safety. We performed a meta-analysis to systematically assess the efficacy and safety of pregabalin for managing pain associated with DPN. ⋯ Our meta-analysis indicates that pregabalin is more effective than placebo for managing DPN-associated pain and other symptoms that reduce quality of life. The drug is also reasonably well tolerated.
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Acta Anaesthesiol Scand · Feb 2015
ReviewEndothelial dysfunction after non-cardiac surgery: a systematic review.
More than 50% of patients with increased troponin levels after non-cardiac surgery have an impaired endothelial function pre-operatively. Non-invasive markers of endothelial function have been developed for the assessment of endothelial dysfunction. The aim of this paper was to systematically review the literature to evaluate the association between non-cardiac surgery and non-invasive markers of endothelial function. ⋯ Endothelial function changes in relation to surgery. Assessment of endothelial function by non-invasive measures has the potential to guide clinicians in the prevention or treatment of post-operative myocardial damage.
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Acta Anaesthesiol Scand · Feb 2015
Editorial CommentThe endothelial glycocalyx: the great luminal barrier.