Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2016
Observational StudyChronic pre-operative opioid use and acute pain after fast-track total knee arthroplasty.
Pre-operative opioid use has been suggested to increase post-operative pain and opioid consumption after total knee arthroplasty (TKA), but previous studies are either retrospective or inhomogeneous with regard to surgical procedures or control of analgesic regimes, or with few opioid-treated patients, hindering firm conclusions. ⋯ Pre-operative opioid use increases the risk for post-operative pain at rest and walk, and increased opioid consumption after TKA.
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Acta Anaesthesiol Scand · Apr 2016
IgM-enriched solution BT086 improves host defense capacity and energy store preservation in a rabbit model of endotoxemia.
The therapeutic value of intravenous immunoglobulin (IVIG) as an adjuvant therapy in sepsis remains debatable. We hypothesized that intravenous administration of BT086, a predominantly IgM IVIG solution, would improve host defense in an established rabbit model of endotoxemia and systemic sepsis. ⋯ Our data suggest that the IgM-enriched IVIG has the potential to improve host defense in a rabbit model of endotoxemia. Studies using different animal models and dosages are necessary to further explore the potential benefits of IgM-enriched IVIG solutions.