Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2016
IgM-enriched solution BT086 improves host defense capacity and energy store preservation in a rabbit model of endotoxemia.
The therapeutic value of intravenous immunoglobulin (IVIG) as an adjuvant therapy in sepsis remains debatable. We hypothesized that intravenous administration of BT086, a predominantly IgM IVIG solution, would improve host defense in an established rabbit model of endotoxemia and systemic sepsis. ⋯ Our data suggest that the IgM-enriched IVIG has the potential to improve host defense in a rabbit model of endotoxemia. Studies using different animal models and dosages are necessary to further explore the potential benefits of IgM-enriched IVIG solutions.