Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2021
Clinical TrialThe 90% effective dose of intranasal dexmedetomidine for procedural sedation in children with congenital heart disease before and after surgery: a biased-coin design up-and-down sequential allocation trial.
Intranasal dexmedetomidine can provide adequate sedation during short procedures. However, there are few reports investigating the effective dose of intranasal dexmedetomidine for sedation in children with congenital heart disease (CHD) before and after surgery. ⋯ The 90% effective dose of intranasal dexmedetomidine for sedation in children with CHD was 2.13 μg/kg before cardiac surgery and 3.51 μg/kg after cardiac surgery.