Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 2021
Non sedation - does it improve health-related quality of life after critical illness? A 3-month follow-up sub-study of the NONSEDA trial.
Critical illness is associated with severely impaired health-related quality of life (HRQoL) for years following discharge. The NONSEDA trial was a multicenter randomized trial on non-sedation versus sedation with a daily wake-up trial in critically ill, mechanically ventilated patients in Scandinavia. The aim of this sub-study was to assess the effect of non-sedation on HRQoL and degree of independence in activities in daily living (ADL) 3 months post-ICU. ⋯ Randomization to non-sedation neither improved nor impaired health-related quality of life or degree of independence in activities in daily living 3 months post-ICU discharge.
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Acta Anaesthesiol Scand · Apr 2021
Efficacy and safety of iloprost in trauma patients with haemorrhagic shock-induced endotheliopathy-Protocol for the multicentre randomized, placebo-controlled, blinded, investigator-initiated shine-trauma trial.
Traumatic injury accounts for 800 000 deaths in the European Union annually. The main causes of deaths in trauma patients are exsanguination and multiple organ failure (MOF). We have studied >1000 trauma patients and identified shock-induced endotheliopathy (SHINE), the pathophysiological mechanism responsible for MOF and high mortality. Pilot studies indicate that low-dose iloprost (1 ng/kg/min) improves endothelial functionality in critically ill patients suggesting this intervention may improve patient outcome in traumatic SHINE. ⋯ This trial will test the safety and efficacy of administration of iloprost vs placebo for 72 hours in trauma patients with haemorrhagic shock-induced endotheliopathy. Trial endpoints focus on the potential effect of iloprost to reduce the need for ICU stay secondary to mitigation of organ failure.
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Acta Anaesthesiol Scand · Apr 2021
Retraction Of PublicationRetraction: Boldt J, Maleck WH, Fent T. Price development in important anesthesia and critical care medicine journals in comparison to journals of other disciplines. Acta Anaesthesiol Scand. 2001;45(4):458-64. https://doi.org/10.1034/j.1399-6576.2001.045004458.x.