Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jan 2022
Randomized Controlled TrialDextran-based priming solution during cardiopulmonary bypass attenuates renal tubular injury - a secondary analysis of randomized controlled trial in adult cardiac surgery patients.
Acute kidney injury (AKI) is a well-known complication after cardiac surgery and cardiopulmonary bypass (CPB). In the present secondary analysis of a blinded randomized controlled trial, we evaluated the effects of a colloid-based versus a conventional crystalloid-based prime on tubular injury and postoperative renal function in patients undergoing cardiac surgery with CPB. ⋯ In patients undergoing cardiac surgery with CPB, colloid-based priming solution (dextran 40) induced less renal tubular injury compared to a crystalloid-based priming solution. Whether a colloid-based priming solution will improve renal outcome in high-risk cardiac surgery, or not, needs to be evaluated in future studies on higher risk cardiac surgery patients.
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Acta Anaesthesiol Scand · Jan 2022
Randomized Controlled TrialProgrammed, intermittent boluses vs. continuous infusion to the sciatic nerve - a non-inferiority randomized, controlled trial.
Trials comparing programmed, intermittent boluses (PIB) and continuous infusion in catheter-based nerve blocks found no analgesic differences. However, as these trials used equal doses of local anesthetic (LA), the time of action of each bolus was not accounted for. Therefore, the dose-sparing benefits of PIB may have been overlooked. We compared the analgesic effect of boluses administered in intervals resembling the time of action of each bolus with continuous infusion. We hypothesized that PIB provided non-inferior analgesia despite consuming less LA. ⋯ PIB provided non-inferior analgesia compared to continuous infusion for 72 postoperative hours despite using significantly less LA.
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Acta Anaesthesiol Scand · Jan 2022
Health-related quality of life, anxiety and depression and physical recovery after critical illness - a prospective cohort study.
Critical illness is often followed by mental and physical impairments. We aimed to assess the health-related quality of life (HRQoL), symptoms of anxiety and depression, and physical function in critically ill patients after discharge from the intensive care unit. ⋯ We found no change in HRQoL, anxiety, and depression, or physical function from 3 months to 1 year. Physical health-related quality of life was impaired at both time points. Subdomain scores for physical health-related quality of life were affected more than mental domains at both time points.
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Acta Anaesthesiol Scand · Jan 2022
Clinical frailty scale: inter-rater reliability of retrospective scoring in emergency abdominal surgery.
Frailty is a complex syndrome shown to be an independent predictor of morbidity and mortality after surgery in older patients. Frailty scoring may, therefore, be important, for example, for pre-operative risk assessment and prognosis estimation. The Clinical Frailty Scale (CFS) has been developed to help operationalize frailty in the individual patient. However, the inter-rater reliability of retrospective CFS scoring through patient records by health care personnel is currently unknown in patients over 80 years of age undergoing emergency abdominal surgery. ⋯ The inter-rater reliability of assigned CFS from patient journals seems acceptable. This could permit retrospective research utilizing CFS measures from several raters and across centers.