Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jan 1999
Randomized Controlled Trial Comparative Study Clinical TrialPeroperative treatment with i.v. ketoprofen reduces pain and vomiting in children after strabismus surgery.
Strabismus surgery is associated with both pain and vomiting. Ketoprofen is widely used in adults to treat acute pain, but there are only few reports of its use in children. This randomised, double-blind, placebo-controlled, parallel group study was designed to investigate the analgesic effect of i.v. ketoprofen and its effect on the incidence of vomiting in children after day-case strabismus surgery. ⋯ We concluded that ketoprofen administered i.v. during the operation produced analgesia and reduced opioid consumption and the incidence of vomiting in children after strabismus surgery.
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Acta Anaesthesiol Scand · Jan 1999
Randomized Controlled Trial Clinical TrialIntra-articular buprenorphine after knee arthroscopy. A randomised, prospective, double-blind study.
Demonstration of peripheral opioid receptors in inflamed synovia supports the concept of peripheral opioid analgesia. The aim of this study was to evaluate the analgesic effect of intra-articular administration of buprenorphine after knee arthroscopy. ⋯ Intra-articular buprenorphine and i.a. bupivacaine, both produced equally good postoperative pain control and allowed a significant reduction of analgesic requirement after knee arthroscopy.
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Acta Anaesthesiol Scand · Jan 1999
Comparative StudyClinical application of diadenosine tetraphosphate (Ap4A:F-1500) for controlled hypotension.
In our animal study, it was revealed that diadenosine tetraphosphate (Ap4A:F-1500) has a dose-dependent hypotension effect of up to 60% decrease in mean arterial pressure compared to control value. Furthermore, in healthy male volunteers, the safety of Ap4A up to 4 mg.min-1 was confirmed. In patients who require surgical procedures under general anesthesia together with controlled hypotension, hypotension was induced by Ap4A in order to examine its hypotensive effect and modulating action on the blood pressure. ⋯ As it produces an excellent hypotensive effect together with a modulating action on blood pressure, Ap4A was assessed as useful in producing controlled hypotension.
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Acta Anaesthesiol Scand · Jan 1999
Randomized Controlled Trial Comparative Study Clinical TrialA large simple randomized trial of rocuronium versus succinylcholine in rapid-sequence induction of anaesthesia along with propofol.
Rocuronium has an onset of action more rapid than other non-depolarizing neuromuscular blocking agents, but it is unclear whether it and succinylcholine give equivalent intubating conditions during rapid-sequence induction of anaesthesia. We performed this study to answer the question--are there clinically relevant differences between the use of rocuronium and succinylcholine to secure acceptable intubating conditions during rapid-sequence induction of anaesthesia with propofol? ⋯ Rocuronium 1.0 mg/kg given along with propofol in a rapid-sequence induction of anaesthesia is clinically equivalent to succinylcholine 1.0 mg/kg.
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Acta Anaesthesiol Scand · Jan 1999
Randomized Controlled Trial Clinical TrialEffects of adenosine infusion on gastric emptying in healthy volunteers.
A low dose of systemic adenosine infusion has been shown to induce antinociception in clinical experimental studies as well as in patients. There is no clinical information about the effect of adenosine on the motility of the gastrointestinal tract. The aim of this study was therefore to evaluate the effect of exogenous adenosine administration on gastric emptying in man. ⋯ The results demonstrate that adenosine in a clinically antinociceptive dose of 50 micrograms.kg-1.min-1 does not affect the rate of gastric emptying in healthy volunteers.