Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Oct 1998
Randomized Controlled Trial Clinical TrialUnilateral spinal anaesthesia with hyperbaric bupivacaine.
The dosage of local anaesthetic and the time the patient must be kept in the lateral decubitus position for a unilateral spinal anaesthesia is not known. The aim of this study was to determine the ideal dosage of hyperbaric bupivacaine and the time required for the lateral decubitus position for a unilateral spinal block. ⋯ For unilateral spinal anaesthesia in lower extremity operations, 2ml 0.5% hyperbaric bupivacaine solution for operations above the knee and 1.5 ml 0.5% hyperbaric bupivacaine solution for operations below the knee and keeping the patients for 10 min in the lateral decubitus position were found to be appropriate.
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Acta Anaesthesiol Scand · Oct 1998
Randomized Controlled Trial Clinical TrialSurgeon's experience as a factor for emetic sequelae after middle ear surgery.
To test the hypothesis that an experienced surgeon is associated with less postoperative nausea and vomiting (PONV). ⋯ The patients operated by residents need more aggressive prophylaxis for PONV than those operated by specialists in middle ear surgery.
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Acta Anaesthesiol Scand · Oct 1998
Spreading pattern of epidurally administered contrast medium in rabbits.
The aim of this study was to examine the precise spreading pattern of epidurally administered contrast medium with small increments of injection volume for determining both the exact volume of the dose required and the site of epidural injection according to different target segments of the spinal cord in a rabbit epidural model. ⋯ In rabbits, it is recommended that at the lower thoracic or lumbar segments the tip of the epidural catheter should be located 1-3 segments below the target segment because of more rostral spread. In the case of mid-thoracic segments, however, placement at the target segment is recommended. In addition, a small titration of volume to achieve a particular range of epidural spread should be required.
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Acta Anaesthesiol Scand · Sep 1998
Randomized Controlled Trial Clinical Trial Retracted PublicationInfluence of dopexamine hydrochloride on haemodynamics and regulators of circulation in patients undergoing major abdominal surgery.
Catecholaminergic support is often used to improve haemodynamics in patients undergoing major abdominal surgery. Dopexamine is a synthetic vasoactive catecholamine with beneficial microcirculatory properties. ⋯ Patients undergoing major abdominal surgery may profit from prophylactic perioperative administration of dopexamine hydrochloride in the form of improved haemodynamics and oxygenation as well as beneficial influence on important regulators of organ blood flow.
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Acta Anaesthesiol Scand · Sep 1998
Randomized Controlled Trial Comparative Study Clinical TrialPharmacokinetics and clinical effect during continuous epidural infusion with ropivacaine 2.5 mg/ml or bupivacaine 2.5 mg/ml for labour pain relief.
Ropivacaine has shown less systemic toxicity than bupivacaine, and comparatively low muscle-blocking properties could constitute another advantage when used epidurally for obstetric pain relief. We aimed primarily to compare maternal and foetal drug disposition following continuous epidural infusion of ropivacaine or bupivacaine. ⋯ A continuous epidural infusion of 25 mg/h ropivacaine or bupivacaine both produced good labour pain relief. Higher total and free plasma concentrations were seen for ropivacaine. The ratios between maternal and umbilical plasma levels were similar for both drugs.