Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Apr 1997
Magnesium--a profibrillatory or antifibrillatory drug depending on plasma concentration, heart rate and myocardial perfusion.
The opinions on the efficacy of magnesium as an antiarrhythmic drug vary considerably. The action of magnesium on vulnerability to fibrillation was therefore investigated in anaesthetized, open-chest pigs under different conditions as regards plasma concentration, heart rate and myocardial perfusion. ⋯ Magnesium may develop profibrillatory or antifibrillatory effects depending on plasma concentration, heart rate and myocardial perfusion.
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Acta Anaesthesiol Scand · Apr 1997
Analysis of anaesthesia in patients suspected to be susceptible to malignant hyperthermia before diagnostic in vitro contracture test.
It is well known that patients susceptible to malignant hyperthermia (MH) do not always develop clinical signs of MH at their first anaesthetic. Large material concerning this epidemiological problem do not exist. Therefore, we undertook the present investigation at the Danish Malignant Hyperthermia Register. ⋯ The clinical expressivity of the MHS phenotype was found to be 34%-54%.
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Acta Anaesthesiol Scand · Apr 1997
Randomized Controlled Trial Clinical TrialNitrous oxide has different effects on the EEG and somatosensory evoked potentials during isoflurane anaesthesia in patients.
Electroencephalogram (EEG) and somatosensory evoked potentials (SEPs) are altered by inhalation anaesthesia. Nitrous oxide is commonly used in combination with volatile anaesthetics. We have studied the effects of nitrous oxide on both EEG and SEPs simultaneously during isoflurane burst-suppression anaesthesia. ⋯ The results suggest that during isoflurane anaesthesia, nitrous oxide has a different effect on EEG and cortical SEP at the same time. The effects of nitrous oxide may be mediated by cortical and subcortical generators.
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Acta Anaesthesiol Scand · Apr 1997
Letter Randomized Controlled Trial Clinical TrialStreptomycin/lignocaine local infiltration in the treatment of hypertrophic scar pain. A preliminary report.
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Acta Anaesthesiol Scand · Apr 1997
Outcome effects of different protective hypothermia levels during cardiac arrest in rats.
Although hypothermia is widely used to protect the brain during cardiac and neurologic surgery, the optimal level of cooling has not been established. This study examined the protective effect of graded levels of surface cooling on cerebral function in rats after complete global cerebral ischemia. ⋯ In this model, moderate (30 degrees C) cooling improved neurologic outcome. There was no additional benefit from more extreme hypothermia.