Journal of paediatrics and child health
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J Paediatr Child Health · Jul 2013
Randomized Controlled Trial Comparative StudyComparison of the pharyngeal pressure provided by two heated, humidified high-flow nasal cannulae devices in premature infants.
This study aims to determine if there is a difference in the pharyngeal pressure, measured as a surrogate for continuous positive distending airway pressure, delivered to premature infants between two commonly used heated, humidified high-flow nasal cannulae (HHHFNC) devices: Fisher & Paykel Healthcare HHHFNC and Vapotherm 2000i. ⋯ Both HHHFNC delivered similar pharyngeal pressures at flow rates of 2-6 L/min. The pressure limiter valve of the Fisher & Paykel device attenuated the pharyngeal pressures at flows of 7 and 8 L/min. Vapotherm trended towards higher delivered pharyngeal pressure at flow rates 7 and 8 L/min, but the clinical significance of the difference remains unclear.
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J Paediatr Child Health · Jun 2013
Randomized Controlled Trial Comparative StudyUsefulness of the fluid balance: a randomised controlled trial in neonates.
To assess the effects of fluid balance charts in neonates with moderate disease severity on duration of hospitalisation and medical interventions. ⋯ Routinely keeping fluid balances in neonates with moderate disease severity does not affect duration of hospitalisation or medical treatment.
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J Paediatr Child Health · Mar 2013
Randomized Controlled TrialBolus fluid therapy and sodium homeostasis in paediatric gastroenteritis.
The study aims to assess the risk of developing hyponatraemia when large-volume bolus fluid rehydration therapy is administered. ⋯ Large-volume bolus rehydration therapy with 0.9% saline is safe. It does not promote the development of hyponatraemia over the short term, but hastens the resolution of baseline hyponatraemia.
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J Paediatr Child Health · Nov 2012
Randomized Controlled Trial Multicenter StudyConducting a paediatric multi-centre RCT with an industry partner: challenges and lessons learned.
There are many benefits of multi-centred research including large sample sizes, statistical power, timely recruitment and generalisability of results. However, there are numerous considerations when planning and implementing a multi-centred study. This article reviews the challenges and successes of planning and implementing a multi-centred prospective randomised control trial involving an industry partner. ⋯ Further, multifaceted ethical and institutional approval processes needed to be negotiated. The challenges, successes, lessons learned and recommendations from this study regarding Australian and New Zealand ethics and research governance approval processes, collaboration with industry partners and the management of differing expectations will be outlined. Recommendations for future multi-centred research with industry partners include provision of regular written reports for the industry partner; continual monitoring and prompt resolution of concerns; basic research practices education for industry partners; minimisation of industry partner contact with participants; clear roles and responsibilities of all stakeholders and utilisation of single ethical review if available.
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J Paediatr Child Health · Mar 2010
Randomized Controlled Trial Comparative StudyTrimethopim-sulfamethoxazole compared with benzathine penicillin for treatment of impetigo in Aboriginal children: a pilot randomised controlled trial.
We conducted a pilot randomized controlled trial comparing trimethoprim-sulfamethoxazole to benzathine penicillin for treatment of impetigo in Aboriginal children. Treatment was successful in 7 of 7 children treated with trimethoprim-sulfamethoxazole and 5 of 6 treated with benzathine penicillin. Trimethoprim-sulfamethoxazole achieved microbiological clearance and healing of sores from which beta-hemolytic streptococci and community-associated methicillin-resistant Staphylococcus aureus were initially cultured.