Acta dermato-venereologica
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Acta Derm. Venereol. · Nov 2016
Cutaneous Porphyrias: Causes, Symptoms, Treatments and the Danish Incidence 1989-2013.
Porphyrias are rare diseases caused by altered haem synthesis leading to the accumulation of different haem intermediates. Neurovisceral attacks may occur in acute porphyrias, while photosensitivity is the presenting symptom in cutaneous porphyrias. ⋯ A total of 650 patients with porphyria cutanea tarda were identified, 73 with erythropoietic protoporphyria, 9 with variegate porphyria, 4 with hereditary coproporphyria and one with congenital erythropoietic porphyria. The total incidence of all porphyrias was ~0.52/100,000 per year.
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Acta Derm. Venereol. · Jun 2016
Psychophysiological Processing of Itch in Patients with Chronic Post-burn Itch: An Exploratory Study.
A substantial proportion of patients with burn injury develop chronic itch, which can severely affect their quality of life. As found in research on chronic pain, different psychophysiological processes may also play a role in chronic itch, of which central sensitization, conditioned modulation, and attentional processes have been studied most frequently. ⋯ Results further suggest that the efficacy of itch modulation by an itch- or pain-conditioning stimulus or directing attention towards itch stimuli do not differ between these patients and controls. Further elucidation of the processes underlying post-burn itch may improve the early identification and treatment of burn patients developing chronic itch.
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Acta Derm. Venereol. · May 2016
Long-term Sequelae of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis.
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions characterized by different extents of epidermal necrosis and mucosal breakdown. A limited number of studies have reported the long-term patterns of SJS and TEN complications in patient populations over long follow-up periods. ⋯ Visceral organ involvement was observed in 2 patients with irreversible deterioration of chronic kidney disease and in one patient with interstitial lung disease. Autoimmune disease was present in 6 patients: Sjögren's syndrome or Sjögren-like syndrome in 5 patients and concomitant systemic lupus erythematosus and Hashimoto thyroiditis in one patient.
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Acta Derm. Venereol. · Mar 2016
Observational StudyClinical Findings and Provision of Care in Haemodialysis Patients with Chronic Itch: New Results from the German Epidemiological Haemodialysis Itch Study.
The German Epidemiological Haemodialysis Itch Study (GEHIS) has shown that more than one-third of haemodialysis (HD) patients have chronic itch (CI). As part of GEHIS, 216 patients with current CI were offered a dermatological examination, of whom 177 were investigated. According to the clinical classification of the International Forum for the Study of Itch (IFSI), 43.5% (n = 77) of the patients examined had CI with no skin lesions (IFSI II), 37.9% (n = 67) had secondary scratch lesions (IFSI III), and 18.6% (n = 33) primarily had diseased skin (IFSI I). ⋯ Only 40.4% (n = 80) had ever sought medical help for CI, 46.4% (n = 32) of whom were in the category IFSI III. Only 32.4% (n = 77) had ever received any treatment for CI and [AQ1] these patients had significantly more severe CI. The current analyses demonstrate that CI is a frequently disregarded symptom in HD patients.