Epidemiology
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Influence of body size and body fat distribution on risk of uterine leiomyomata in U.S. black women.
Uterine leiomyomata are a major source of morbidity in black women. We prospectively investigated the risk of self-reported uterine leiomyomata in relation to body mass index (BMI), weight change, height, waist and hip circumferences, and waist-to-hip ratio in a large cohort of U.S black women. ⋯ BMI and weight gain exhibited a complex relation with risk of uterine leiomyomata in the Black Women's Health Study. The BMI association was inverse J-shaped and findings were stronger in parous women. Weight gain was positively associated with risk among parous women only.
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Perinatal epidemiology studies often collect only the calendar month in which an event occurs in early pregnancy because it is difficult for women to recall a specific day when queried later in pregnancy or postpartum. Lack of day information may result in incorrect assignment of completed gestational month because calendar months and pregnancy months are not aligned. ⋯ Calendar month difference, a common method, has the greatest misclassification. Conditional month difference and imputed month midpoint, which require little effort to implement, are superior to calendar month difference for reducing misclassification.
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Biography Historical Article
Assessing the contributions of John Snow to epidemiology: 150 years after removal of the broad street pump handle.
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Historical Article
"The pump don't work, 'cause the vandals took the handles".
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Study of the influence of physical activity and body composition in the context of the disablement process requires analytic techniques that can address time-dependent confounding related to exposures for the occurrence of functional limitation and disability. ⋯ Marginal structural models provide a means to address time-dependent confounding, which can occur in longitudinal studies. These analyses indicate that leisure time physical activity exerts its beneficial effects through reductions in fat mass relative to lean body mass.