Journal of cardiovascular electrophysiology
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J. Cardiovasc. Electrophysiol. · Apr 2015
Effects on repolarization using dynamic QT interval monitoring in long-QT patients following left cardiac sympathetic denervation.
Videoscopic left cardiac sympathetic denervation (LCSD) is an adjunct therapy for reduction of arrhythmia-induced events in patients with long-QT syndrome (LQTS). LCSD reduces LQTS-triggered breakthrough cardiac events. The temporal effects of QTc changes post-LCSD have not been studied. ⋯ Although LQTS patients may have a paradoxically increased QTc post-LCSD, the effects are transient in most patients. Importantly, no patients experienced any arrhythmias in the postoperative setting related to this transient rise in QTc.
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J. Cardiovasc. Electrophysiol. · Mar 2015
Feasibility and efficacy of percutaneously delivered leadless cardiac pacing in an in vivo ovine model.
In this in vivo ovine study, we describe the course of pacing and sensing parameters during follow-up as well as the gross and histopathological features at the implant site of the recently described leadless cardiac pacemaker (LCP). ⋯ We demonstrate that after implantation of the LCP, pacing/sensing parameters remain adequate up to 18 months in follow-up. In addition, pathological changes at the implant site and within the RV are limited in severity at 90 days, supporting the efficacy and safety of this novel approach to pacing.
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J. Cardiovasc. Electrophysiol. · Feb 2015
Randomized Controlled Trial Multicenter Study Comparative StudyCatheter ablation for ventricular tachycardia in patients with an implantable cardioverter defibrillator (CALYPSO) pilot trial.
We conducted this pilot randomized clinical trial to determine the feasibility of a large clinical trial aimed at testing whether early use of catheter ablation of ventricular tachycardia (VT) is superior to antiarrhythmic medications at reducing mortality. ⋯ This clinical trial shows that most patients in clinical practice have already failed antiarrhythmic drug therapy before catheter ablation is considered, and the VT recurrence rates and death in these patients are high. For a large clinical trial to be feasible, factors limiting early consideration of catheter ablation need to be identified and addressed.
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J. Cardiovasc. Electrophysiol. · Feb 2015
Randomized Controlled Trial Comparative StudyRate-control drugs affect variability and irregularity measures of RR intervals in patients with permanent atrial fibrillation.
Irregularity measures have been suggested as risk indicators in patients with atrial fibrillation (AF); however, it is not known to what extent they are affected by commonly used rate-control drugs. We aimed at evaluating the effect of metoprolol, carvedilol, diltiazem, and verapamil on the variability and irregularity of the ventricular response in patients with permanent AF. ⋯ Modification of AV node conduction by rate-control drugs increase RR variability, while only β-blockers affect irregularity.
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J. Cardiovasc. Electrophysiol. · Feb 2015
ReviewRenal denervation for treatment of cardiac arrhythmias: state of the art and future directions.
It has now been more than a quarter of a century since modulation of the sympathetic nervous system was proposed for the treatment of cardiac arrhythmias of different origins. But it has also been some time since some of the early surgical attempts have been abandoned. ⋯ This review focuses on the possible impact of renal sympathetic system modulation on cardiac arrhythmias, the current evidence supporting this approach, and the ongoing trials of this method in electrophysiological laboratories. We will discuss the potential roles that sympathetic modulation may play in the future.