Archives of orthopaedic and trauma surgery
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Arch Orthop Trauma Surg · Jul 2001
Hip arthropathy associated with hemodialysis. Radiological and laboratory evaluation of 56 hemodialysis patients.
There were 56 consecutive patients enrolled in our study from the outpatient clinic of our institution, mean age of 59 years, who had been on hemodialysis for 2-26 years. The duration of hemodialysis was less than 10 years for 36 patients (short-term group) and 10 years or more for 20 patients (long-term group) with a mean duration of 11 years at time of the investigation. In the short-term group, plain radiography revealed bone cysts in 9 hips (17%) and joint space narrowing in 10 hips (19%), while in the long-term group, there were bone cysts in 19 hips (48%) and joint space narrowing in 6 hips (15%). ⋯ Hip arthroplasties were performed in 3 patients suffering from femoral neck fracture due to bone cysts. All of them showed marked bone loss (mean 0.380 g/cm2). In conclusion, plain radiography and dual-energy X-ray absorptiometry are useful for evaluating the hip arthropathy of hemodialysis patients, especially those who have undergone long-term hemodialysis.
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Arch Orthop Trauma Surg · Jul 2001
The contribution of vitamin C to healing of experimental fractures.
The benefits of various minerals and vitamins on fracture healing have been demonstrated in animal models. Vitamin C is an essential substance in fracture healing but has not been studied previously on an experimental basis. Sixteen rats were grouped randomly into control and vitamin C-supplemented groups. ⋯ One group received single high dose of vitamin C intramuscularly. On the 5th, 10th, 15th, and 20th days, two rats from each group were killed and the tibias examined under light microscopy. It was seen that the vitamin C-supplemented group went through the stages of fracture healing faster compared with the control group.
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Arch Orthop Trauma Surg · Jul 2001
Immunolocalization of the angiogenetic factor pleiotrophin (PTN) in the growth plate of mice.
The aim of this study was to find out whether and where the angiogenic agent pleiotrophin (PTN) occurs within the growth plate. We investigated paraffin-embedded tissue sections of ten male mice with an antibody directed against the recombinant PTN. ⋯ The resting zone and the proliferation zone were PTN negative. The results of our study suggest that the known angiogenetic peptide PTN plays a role in the process of angiogenesis in the growth plate.