Coronary artery disease
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Coronary artery disease · Jun 2003
Temporary cessation of spinal cord stimulation in angina pectoris-effects on symptoms and evaluation of long-term effect determinants.
Spinal cord stimulation (SCS) has been used since 1985 for patients with refractory angina pectoris. Spinal cord stimulation has anti-ischaemic effects and reduces angina effectively. After long-term treatment, temporary cessation of stimulation may occur due to SCS battery depletion or electrode fracture. The aim of the present study was to assess anginal symptoms and functional status during SCS dysfunction and after its restitution. ⋯ This study indicates that SCS relieves angina effectively also after long-term treatment, without development of tolerance. The findings suggest that mechanisms other than placebo and spontaneous variation of symptoms are responsible for the improvement in angina during SCS.
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Coronary artery disease · May 2003
Comparative StudyProlongation of the QT-corrected interval during dobutamine stress echocardiography: a marker for ischemia.
Dobutamine stress echocardiography (DSE) has become a very reliable non-invasive tool in the diagnosis of ischemic heart disease based on the determination of new wall motion abnormalities rather than electrocardiographic changes. ⋯ These results suggest that the development of new wall motion abnormalities suggestive of ischemia during DSE is associated with prolongation of the QTc interval and delayed heart rate early in the recovery period. These two parameters should be further studied not only as additional markers in the identification of ischemia in patients referred for DSE but also to assess their potential significance during short- and long-term follow-up.
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Coronary artery disease · Jun 2002
Comparative StudyDifferential efficacy of different platelet glycoprotein IIb/IIIa antagonists on platelet/fibrin-mediated clot dynamics under different conditions using thrombelastography: the critical need for anticoagulant.
Intravenous GpIIb/IIIa antagonists demonstrate various significant clinical benefits depending on the agent used. In contrast, oral delivery of GpIIb/IIIa antagonists failed in achieving clinical benefits. This raises the question about the differences among different GpII/IIIa antagonists. ⋯ Thus, these data indicated that there are differences in the efficacy of various GPIIb/IIIa antagonists in inhibiting platelet/fibrin clot formation and strength, which might be corrected by heparin. Data also suggest that inhibition of platelet aggregation may not be the sole determinant for the in-vivo efficacy of various GPIIb/IIIa antagonists.
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Coronary artery disease · Jun 2002
Clinical and angiographical characteristics of acetylcholine- induced spasm: relationship to dose of intracoronary injection of acetylcholine.
The purpose of this study was to clarify clinical and angiographical characteristics of acetylcholine (ACh)-induced spasm in the right and left coronary artery. ⋯ Lower ACh doses induced spasms more proximally and focally in the coronary artery, while higher doses of ACh provoked spasms more distally and diffusely.