Journal of dermatological science
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Knowledge of changes in lymphatic flow after sentinel lymph node biopsy (SLNB) is important for the development of strategies for postoperative adjuvant therapy in malignant melanoma. ⋯ We clearly demonstrated that SLNB has only a minimal effect on lymphatic flow. The present results suggest that SLNB does not increase the risk of local recurrence/in-transit metastasis and may support the efficacy of post-SLNB local adjuvant injection to prevent local recurrence and in-transit metastasis.
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Alopecia areata (AA) is a common immune-mediated hair loss disorder. Despite its high prevalence, its etiology is still largely unknown, but it is hypothesized to have a strong genetic basis. In the last decade, there has been a major progress in the field of genetic research, leading to novel findings regarding the genetic component of AA. The aim of this review is to summarize the information collected so far in this field, the basic principles of the genetic methods used in previous studies, and new therapeutic strategies that might become available in light of the new findings.
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In patients with rosacea, environmental stressors, especially UVB radiation, trigger disease flares that are characterized by inflammation and vascular hyperactivity. An altered innate immune detection and response system, modulated to a large extent by the aberrant production and processing of human cathelicidin LL-37, is thought to play a central role in disease pathogenesis. ⋯ Cathelicidin LL-37 modulates the proinflammatory and proangiogenic effects of UV radiation and thereby contributes to enhanced sensitivity to sun exposure in rosacea.