Annals of epidemiology
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Annals of epidemiology · Sep 2006
Correlation between incidences of self-inflicted burns and means of inbreeding coefficients, an ecologic study.
The aim of the study is to obtain more insight into the possible association between consanguinity and the incidence of deliberate self-burning. ⋯ In addition to other factors, consanguineous marriage may be a risk factor that influences the incidence of suicidal burns in a population.
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Annals of epidemiology · Jan 2006
Comparative StudyDisparities in mortality among high risk pregnant women in Illinois: a population based study.
Researchers are increasingly studying maternal mortality in the context of maternal morbidity in order to identify risk and protective factors operating at each point along the morbidity-mortality continuum. This study examined factors associated with mortality in pregnant women with severe morbidity. In particular, the Black-White disparity was examined. ⋯ Medical risk status alone cannot explain disparities in maternal mortality. The Black-White disparity for risk of death persisted in both overall and condition-specific analyses.
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Annals of epidemiology · Jan 2006
Randomized controlled trials with time-to-event outcomes: how much does prespecified covariate adjustment increase power?
We evaluated the effects of various strategies of covariate adjustment on type I error, power, and potential reduction in sample size in randomized controlled trials (RCTs) with time-to-event outcomes. ⋯ Adjustment for one predictive baseline characteristic yields greater power to detect a true treatment effect than unadjusted analysis, without inflation of type I error and with potentially moderate reductions in sample size. Analysis of RCTs with time-to-event outcomes should adjust for predictive covariates.
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Annals of epidemiology · Oct 2005
Ethical issues associated with conducting genetic family studies of complex disease.
To examine subjects' recognition of the risks and ethical issues associated with enrollment in genetic family studies (GFS) and explore how this recognition affects their informed and voluntary participation. ⋯ Subjects enrolled in GFS did not recognize and tended to underestimate the social and cultural risks associated with their participation in GFS. If subjects do not fully comprehend the risks, this raises questions concerning their ability to provide informed consent and to voluntarily participate. We propose a subject-centered approach that views enrollment as an active process in which subjects and recruiters give and receive information on risks and ethical issues related to participation, which enhances protection of the rights and welfare of subjects participating in GFS.