Acta obstetricia et gynecologica Scandinavica
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Acta Obstet Gynecol Scand · Dec 2012
Angiogenic factors in maternal circulation and preeclampsia with or without fetal growth restriction.
To study associations of placental growth factor (PlGF) and soluble fms-like tyrosine kinase 1 (sFlt-1) in maternal circulation with the risk of preeclampsia with and without fetal growth restriction. ⋯ Low PlGF and high sFlt-1 levels in maternal circulation are associated with subsequent development of preeclampsia, regardless of whether fetal growth is affected or not. For term preeclampsia without fetal growth restriction, the imbalance in angiogenic factors seems to appear later in pregnancy than for preterm preeclampsia.
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Acta Obstet Gynecol Scand · Dec 2012
ReviewThe impact of vitamin D on pregnancy: a systematic review.
Hypovitaminosis D is common in pregnancy. To systematically review the evidence on vitamin D-dependent pregnancy outcomes, PubMed and Embase were searched for randomized control trials, cohort and case-control studies. In randomized control trials (n = 7), larger doses of vitamin D resulted in higher 25-hydroxylated vitamin D (25OHD) levels (n = 6), increased maternal weight gain (n = 1), and fewer classical vitamin D deficiency symptoms (n = 1). ⋯ Studies with few participants having low 25OHD did not identify an association to preeclampsia (n = 5) or gestational diabetes (n = 2). Increased odds of pregnancy-associated breast cancer with 25OHD >25.8 nmol/L were observed (n = 1). In conclusion, an effect of vitamin D on several pregnancy outcomes is suggested.
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Acta Obstet Gynecol Scand · Dec 2012
Randomized Controlled TrialIntraoperative injection of bupivacaine-adrenaline close to the fascia reduces morphine requirements after cesarean section: a randomized controlled trial.
The purpose of this study was to investigate whether a single injection of bupivacaine with adrenaline close to the fascia could decrease opiate consumption and pain in patients undergoing cesarean section in spinal anesthesia. ⋯ A single injection of bupivacaine with adrenaline in the surgical wound decreases the need for morphine requirements for the first 12 postoperative hours and contributes to safe and effective pain management in women undergoing cesarean section.
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Acta Obstet Gynecol Scand · Nov 2012
Follow-up of gynecological cancer patients after treatment - the views of European experts in gynecologic oncology.
Follow-up after treatment for gynecological cancer demands large resources. There is a lack of evidence of efficacy. The aim of this survey was to explore follow-up routines and views on follow-up care among European experts in gynecological oncology. ⋯ Follow-up routines after gynecological cancer vary in Europe. According to the majority of the responders of this survey targeting European experts in gynecological oncology, follow-up by GPs may be an option for low-risk patients. New follow-up routines should preferentially be based on prospective trials comparing conventional follow-up of gynecological cancer patients with alternative methods of care, assessing survival, detection of recurrence, and quality of life.
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Acta Obstet Gynecol Scand · Oct 2012
Serum soluble urokinase plasminogen activator receptor (suPAR) in early pregnancy prior to clinical onset of preeclampsia.
To examine whether soluble urokinase plasminogen activator receptor (suPAR) in early pregnancy could be a risk marker for later development of preeclampsia. ⋯ suPAR did not appear to be a useful early pre-clinical marker of preeclampsia.