Cerebrovascular diseases
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Cerebrovascular diseases · Jan 2010
The temporal profile of inflammatory markers and mediators in blood after acute ischemic stroke differs depending on stroke outcome.
Early inflammation has been suggested as an important factor contributing to unfavorable prognosis after acute ischemic stroke. The present study aimed to clarify the temporal dynamics of discrete inflammatory markers/mediators for future mechanism-targeting anti-inflammatory strategies in ischemic brain damage. ⋯ Our data show important differences in the early time course of several potential markers for the complex network of inflammation and brain damage after ischemic stroke depending on stroke outcome. This must be considered for any therapeutical approach using anti-inflammatory treatment.
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Cerebrovascular diseases · Jan 2010
Association of platelet and leukocyte counts with delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage.
A proinflammatory prothrombotic state may increase the risk of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH). We studied the relationship of levels of leukocytes, platelets, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) with the development of DCI and with clinical outcome in patients with aneurysmal SAH. ⋯ Counts of platelets and leukocytes disproportionally increase during the occurrence of DCI after aneurysmal SAH. Drugs with anti-thrombotic or anti-inflammatory properties should be studied for prevention and treatment of DCI.
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Cerebrovascular diseases · Jan 2010
Cardiovascular risk and neuroradiological profiles in asymptomatic vertebrobasilar dolichoectasia.
Clinicoradiological variability of vertebrobasilar dolichoectasia (VBD) is known. Little is known about cardiovascular disease (CVD) risk and neuroradiological profiles of asymptomatic VBD. ⋯ Asymptomatic VBD was detected in 1.3% of the Japanese PC group. Our data indicated male predominance, multiple CVD risk factors, neurovascular hypertension and small infarcts in asymptomatic VBD.
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Cerebrovascular diseases · Jan 2010
Transient ischemic attack after tissue plasminogen activator: aborted stroke or unnecessary stroke therapy?
The frequency with which intravenous thrombolysis for acute ischemic stroke results in normal clinical and radiographic status is currently unknown. ⋯ Over 10% of patients who receive tPA for cerebral ischemia do not develop ischemic injury. tPA use for a nonischemic process is infrequent but is associated with community hospital use.
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Cerebrovascular diseases · Jan 2010
Site of ruptured intracranial saccular aneurysms in patients in Izumo City, Japan.
A community-based study was conducted to estimate the site distribution of ruptured intracranial aneurysms and to evaluate clinical features related to aneurysm site. ⋯ The roughly estimated proportions of the sites of aneurysm rupture were 40% for the ACA, including ACoA and distal ACA, 25% for the ICA, 25% for the MCA, and 10% for the VBA. The clinical features showed significant differences according to aneurysm site.