Cerebrovascular diseases
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Cerebrovascular diseases · Jan 2008
Controlled Clinical TrialCerebral autoregulation dynamics in acute ischemic stroke after rtPA thrombolysis.
To investigate whether there is: (1) a specific temporal course of cerebral dysautoregulation in acute ischemic stroke, and (2) a separate detrimental effect of recombinant tissue plasminogen activator (rtPA) on autoregulation dynamics in this situation. ⋯ Cerebral autoregulation is increasingly impaired, mainly on the affected side, over the first 5 days of major ischemic stroke after unsuccessful rtPA thrombolysis. It is bilaterally preserved in minor stroke after successful rtPA thrombolysis, indicating no separate detrimental effect of rtPA on the cerebral autoregulatory mechanism.
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Cerebrovascular diseases · Jan 2008
Controlled Clinical TrialProspective evaluation of multidetector-row CT angiography for the diagnosis of vasospasm following subarachnoid hemorrhage: a comparison with digital subtraction angiography.
To evaluate the accuracy of multidetector-row CT angiography (CTA) for the diagnosis of large-vessel vasospasm following subarachnoid hemorrhage by comparison to digital subtraction angiography (DSA). ⋯ Compared to the gold standard of DSA, CTA is accurate for the detection of large-vessel vasospasm, and has a very high NPV.
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Cerebrovascular diseases · Jan 2008
ReviewUse of 31P magnetic resonance spectroscopy to study the effect of cortical magnesium and energy metabolism after subarachnoid hemorrhage.
Flow metabolism coupling ensures adequate cerebral oxygenation. When subarachnoid hemorrhage (SAH) occurs, the flow metabolism coupling lost its balance and results in cerebral ischemia and infarction second to cortical magnesium and energy metabolism alternation. During chronic vasospasm, change in cortical energy metabolism is coupled with change in cerebral blood flow after SAH. ⋯ (31)P MRS data, combined with other MRI sequences, provide a comprehensive assessment of both structural and functional deficits and a guidance on clinical therapy for SAH.
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Cerebrovascular diseases · Jan 2008
Improved detection of intracerebral hemorrhage with transcranial ultrasound perfusion imaging.
Ultrasound perfusion imaging (UPI) is a new approach for the assessment of brain perfusion. In contrast to the increasing experience with this method in patients with ischemic stroke, data on the value of UPI for the diagnosis of intracerebral hemorrhage (ICH) are lacking. ⋯ This study supports earlier work demonstrating the usefulness of native transcranial ultrasound for the diagnosis of ICH. UPI further improves diagnostic reliability and allows very precise ICH volume measurements. If confirmed in larger studies, this approach may be useful for bedside monitoring of ICH progression and regression.
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Cerebrovascular diseases · Jan 2008
The role of high-sensitivity C-reactive protein in asymptomatic intra- and extracranial large artery diseases.
It remains unclear whether high-sensitivity CRP (hs-CRP) is predictive of atherosclerosis in the intracranial artery. The aim of this study is to assess the role of hs-CRP in asymptomatic intracranial artery occlusive diseases. ⋯ The degree of atherogenic inflammation in asymptomatic intracranial artery stenosis may be less than that in extracranial carotid artery stenosis.