Acta oto-laryngologica
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Acta oto-laryngologica · Sep 2007
Comparative StudyExperimental comparative study in rabbits of three different ways of cartilage graft fixation: suture, gelatin-resorcin-formaldehyde and butyl-2-cyanoacrylate.
The compound gelatin-resorcin-formaldehyde (GRF) was a better stabilizing material for cartilage grafts in rabbits than butyl-2-cyanoacrylate. GRF was also better than the suture when comparing fixation of cartilage to the periosteum and inflammatory reaction. ⋯ There was less migration of the cartilages glued with GRF than with cyanoacrylate and suture. GRF showed statistically less inflammatory reaction and angiogenesis than the other two methods. The three methods showed a tendency to decrease of fibrosis, inflammation, and angiogenesis as weeks passed. There was no detachment or deformity in the cartilage sandwiches sutured to the glabella's periostium. The majority of detached and deformed cartilages were those glued with cyanoacrylate. The number of detached cartilages was directly related to the number of deformed cartilages. The data were statistically significant (p<0.05).
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Acta oto-laryngologica · May 2007
Differential gene expression profiles in salicylate ototoxicity of the mouse.
This study demonstrated differential gene expression profiles in salicylate ototoxicity with oligonucleotide microarray. This study may also provide basic information on candidate genes associated with hearing loss and/or tinnitus or recovery after salicylate-induced cochlear dysfunction. ⋯ No ultrastructural changes in the mice cochlea were observed by TEM at 3 h after salicylate injection. Microarray revealed that 87 genes were up-regulated twofold or more in the mouse cochlea with salicylate ototoxicity in comparison to the normal cochlea. Among these genes, increased expression levels of 30 functional genes were confirmed by semi-quantitative RT-PCR.
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Acta oto-laryngologica · Apr 2007
Impact of a self-developed planning and self-constructed navigation system on skull base surgery: 10 years experience.
Our self-developed planning and navigation system has proven its capacity for accurate surgery on the anterior and lateral skull base. With the incorporation of augmented reality, image-guided surgery will evolve into 'information-guided surgery'. ⋯ Using our navigation system, no major complications occurred in spite of the fact that the series included difficult skull base procedures. An improved quality in the surgical outcome was identified compared with our control group without navigation and compared with the literature. The surgical time consumption was reduced and more minimally invasive approaches were possible. According to the participants' questionnaires, the educational effect of the virtual simulator in our residency program received a high ranking.
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Acta oto-laryngologica · Apr 2007
Medical education by bedside learning - helping medical students to interact with patients who have head and neck cancer.
Our bedside interviews with patients with head neck cancer are unique and valuable educational experiences for undergraduate medical students. ⋯ Before the bedside teaching our medical students believed that it must be important to listen to patients (100%); and that it must be possible to encourage patients (50%). After the bedside teaching they noticed that a medical interview could have a positive influence on the patient (93%), probably because of general conversation (45%), the patient's personality (50%), listening to information about the patient's birthplace, education, occupation and hobby (48%), and the instructor's life experiences (25%). Most patients asked medical students to be good doctors who can understand their thoughts and feelings.
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Acta oto-laryngologica · Mar 2007
Comparative StudyA completed audit cycle on post-tonsillectomy haemorrhage rate: coblation versus standard tonsillectomy.
A significant reduction in post-tonsillectomy secondary haemorrhage rate was observed after coblation tonsillectomy was abandoned in our department. ⋯ The overall primary haemorrhage rate in the first audit cycle was 1.8% (8/441). In the second cycle with no coblation procedures, 1.4% of patients (6/416) suffered from primary haemorrhage (c.f. 8/441 (1.8%) in the first cycle, p=0.666). Secondary haemorrhage, was seen among 15.4% of patients (68/441) in the first audit cycle. In the second cycle, after coblation was discontinued, the secondary haemorrhage rate fell significantly (p<0.001) to 5.8% (24/416). A breakdown of the results of cold steel/diathermy and coblation techniques in both adults and children is also presented.