Journal of neuroimaging : official journal of the American Society of Neuroimaging
-
Amnestic mild cognitive impairment (aMCI) is associated with the risk of Alzheimer's disease (AD). Although diffusion tensor imaging (DTI)-based fractional anisotropy (FA) analyses have been used to evaluate white matter changes in patients with AD, it remains unknown how FA values change during the conversion of aMCI to AD. This study aimed to elucidate the prediction of conversion to AD and cognitive decline by FA values in uncinate fasciculus (UF) in aMCI patients. ⋯ These results suggested that FA values in the right UF might be an effective predictor of conversion of aMCI to AD.
-
Alzheimer's disease (AD) patients show early changes in white matter (WM) structural integrity. We studied the use of diffusion tensor imaging (DTI) in assessing WM alterations in the predementia stage of mild cognitive impairment (MCI). ⋯ Our results suggest that DTI data provide better prediction accuracy than GM volume in predementia AD.
-
Investigate the relative frequency of nonlesional versus lesional hypertrophic olivary degeneration (HOD) and potential explanations for nonlesional HOD. ⋯ Forty-four percent of patients with HOD did not demonstrate an MRI-identifiable lesion in the DROP, and 45% of those patients did not have identifiable brain lesions outside of the DROP. Thus, nearly a fifth of HOD cases may be truly idiopathic. A majority of patients without a DROP lesion had bilateral HOD and two-thirds were male.
-
Optic neuritis (ON) is an acute episode of inflammation in the visual pathway (VP). It may occur as part of a demyelinating disease, which can affect white matter (WM) throughout the VP. Compensatory cortical adaptations may occur following WM damage to maintain visual integrity. Our aim was to investigate whether resting-state functional MRI (rsfMRI) can detect cortical adaptations following ON attacks and to correlate rsfMRI with diffusion tensor imaging (DTI) of WM within the VP. ⋯ The rsfMRI detected cortical reorganization following ON attack, but WM was considerably preserved in the posterior VP.
-
Ephedrone encephalopathy is referred to as a group of symptoms of manganese deposition within the central nervous system (CNS), resulting from the abuse of ephedrone (methcathinone), obtained in reaction using the excess amount of manganese-containing oxidants. The diagnosis is based on the contrast-enhanced head MRI findings characteristic for this syndrome, clinical manifestation and history of ephedrone use. The syndrome has been reported in recent years in young people from Eastern Europe and Russia with a history of ephedrone overuse. However, no report has ever been published on ephedrone encephalopathy in Polish patients.