Journal of neuroimaging : official journal of the American Society of Neuroimaging
-
To evaluate the short-term outcome of erythropoietin (EPO) therapy in rats with spinal cord injury (SCI) using manganese-enhanced magnetic resonance imaging (MEMRI). ⋯ MEMRI successfully depicts the therapeutic effect of EPO in early SCI that leads to a significant recovery in rats, a significantly reduced immune response and significantly reduced number of apoptotic cells at the height of the lesion epicenter.
-
A 41-year-old woman presented with acute onset headache, vertigo, nausea, and gait disorder, initially interpreted as a common cold. Within 2 weeks, she developed a severe opsoclonus-myoclonus syndrome with truncal ataxia. ⋯ Corresponding PET findings were able to depict the response to therapy in the ocular muscles and the inferior vermis, whereas the deep cerebellar nuclei were still hyperactivated, however, to a lesser extent. This finding highlights the usefulness of functional/metabolic brain imaging to study the pathophysiology of this type of disorder.
-
Working memory impairment is among the earliest signs of cognitive decline in Alzheimer's disease (AD) and mild cognitive impairment (MCI). We aimed to study the functional and structural substrate of working memory impairment in early AD dementia and MCI. ⋯ Our findings suggest that impairments of structural fiber tract integrity accompany breakdown of posterior and relatively preserved anterior cortical activation during working memory performance in MCI/AD subjects.
-
Review Case Reports
Chiasmatic-hypothalamic masses in adults: a case series and review of the literature.
Chiasmatic-hypothalamic masses are commonly seen in children with neurofibromatosis type 1 and often demonstrate a benign clinical course. These masses are, however, rare in adults and require tissue sampling for diagnosis. Here, we present four cases of chiasmatic-hypothalamic masses in adults with pathologically proven diagnoses. We also provide a review of the literature and propose a limited differential in this age group.