Enfermedades infecciosas y microbiología clínica
-
Enferm. Infecc. Microbiol. Clin. · Mar 2006
[Cytomegalovirus detection in blood and bronchoalveolar lavage, and prophylaxis or preemptive treatment with ganciclovir in children with allogeneic stem cell transplantation].
Cytomegalovirus disease is one of the complications of allogeneic stem cell transplantation (SCT). The objective of this study was to determine the frequency of CMV infection and CMV disease in children undergoing allogeneic SCT, and in whom antigenemia and bronchoalveolar lavage (BAL) were performed for early detection of CMV infection. ⋯ As compared to other series, a lower frequency of CMV disease and a reduction in ganciclovir use were observed with this strategy.
-
Enferm. Infecc. Microbiol. Clin. · Dec 2005
Review[Treatment of uncomplicated lower urinary tract infections].
Empirical antibiotic treatment of lower urinary tract infections should be based on the patient's clinical data and on local sensitivity data. Because of the increase in resistance among uropathogens, recommendations on the empirical treatment of urinary tract infections have been modified. Currently, the empirical use of co-trimoxazole, ampicillin, and first-generation cephalosporins and quinolones is not recommended. ⋯ Fosfomycin-trometamol has resistance rates of below 2% and single-dose therapy has been demonstrated to be safe and effective. Nitrofurantoin is also currently active, although it must be administered for 7 days and can produce toxicity. Both agents are currently recommended as alternative therapeutic options to fluoroquinolones in uncomplicated infections of the lower urinary tract.
-
Enferm. Infecc. Microbiol. Clin. · Dec 2005
Review[Nosocomial pneumonia due to Acinetobacter baumannii].
Acinetobacter baumannii is a significant cause of nosocomial pneumonia, especially late ventilator-associated pneumonia. In Spain, A. baumannii is the third leading pathogen after Pseudomonas aeruginosa and Staphylococcus aureus. Risk factors for pneumonia due to A. baumannii are head injury, neurosurgery, acute respiratory distress syndrome, aspiration, and previous antibiotic therapy. ⋯ The associations of imipenem and rifampin or imipenem and sulbactam may be acceptable alternatives to colistin in infections caused by these strains. Surveillance measures are essential to eradicate this multidrug-resistant pathogen in outbreaks and reduce the number of episodes in endemic situations. Although these measures are important throughout the hospital, intensive care units are especially high-risk areas.
-
Enferm. Infecc. Microbiol. Clin. · Dec 2005
Review[Pathogenesis and environmental factors in ventilator-associated pneumonia].
Respiratory infections in intubated patients can derive from endogenous or exogenous sources. The major route for acquiring endemic ventilator-associated pneumonia (VAP) is oropharyngeal colonization by endogenous flora and leakage of contaminated secretions into the lower respiratory tract. However, a not inconsiderable percentage of VAP results from exogenous nosocomial colonization, especially pneumonias caused by resistant bacteria such as methicillin-resistant Staphylococcus aureus and multiresistant Acinetobacter baumannii or Pseudomonas aeruginosa, as well as by Legionella spp or filamentous fungi, such as Aspergillus. This article reviews the pathogenesis of VAP and the role of the intensive care environment as a source of pathogenic microorganisms.
-
Enferm. Infecc. Microbiol. Clin. · Dec 2005
Review[Hospital-acquired pneumonia in the non-ventilated patient].
Hospital-acquired pneumonia is one of the main causes of nosocomial infection. Although its incidence is higher in intubated patients, around half of all cases occur outside the intensive care unit (ICU). ⋯ The epidemiological differences between intubated patients and non-ICU patients suggest that the etiology and therapeutic approach differ between these two groups. The present article reviews the epidemiology, diagnosis, treatment and prevention of nosocomial pneumonia in general wards.