Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Aug 2004
Diffusion anisotropy in subcortical white matter and cortical gray matter: changes with aging and the role of CSF-suppression.
To determine the relevance of cerebrospinal fluid (CSF)-suppression for the measurement of diffusion anisotropy in well-localized areas of the brain, particularly the subcortical white matter (WM) within the gyri and cortical gray matter (GM), in young and elderly subjects, and to assess the changes of water diffusivity in the brain with normal aging. ⋯ CSF-suppressed DTI yields more accurate measures of quantitative anisotropy in cortical and subcortical brain regions. Reductions of anisotropy with aging were predominantly observed in subcortical WM of the gyri.