Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · May 2008
Gadolinium-based contrast agents and their potential role in the pathogenesis of nephrogenic systemic fibrosis: the role of excess ligand.
To investigate the role of excess ligand present in gadolinium (Gd) -based contrast agents in the development of nephrogenic systemic fibrosis (NSF). Using a dosing regimen to simulate the exposure seen in patients with severe renal impairment, we investigated the effect of excess ligand on Gd-deposition and the depletion of endogenous ions. ⋯ Our findings suggest that there is an inverse correlation between the amount of excess ligand present in Gd-containing contrast agents and the amount of Gd in the tissue, and further underline the importance of the inherent stability of these agents in the development of NSF.
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J Magn Reson Imaging · May 2008
Diffusion-weighted magnetic resonance imaging allows monitoring of anticancer treatment effects in patients with soft-tissue sarcomas.
To determine if diffusion-weighted imaging (DWI) can be used as a surrogate marker of tumor response to anticancer therapy in patients with soft-tissue sarcomas. ⋯ DWI can be used as a supplement to morphologic imaging for the evaluation of tumor response to anticancer therapy in patients with soft-tissue sarcomas. As cellular changes are expected to precede morphologic changes in treated tumors, DWI performed at an early stage of fractionated therapy may provide unique prognostic information of its effectiveness.
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J Magn Reson Imaging · May 2008
MR-guided core biopsy with MR fluoroscopy using a short, wide-bore 1.5-Tesla scanner: feasibility and initial results.
To evaluate MR fluoroscopy in a short, wide-bore 1.5T MRI suitable for near real-time biopsy guidance. ⋯ Findings of this study demonstrate that MR fluoroscopy for biopsy guidance in a short, wide-bore 1.5T scanner is feasible. This scanner combines the patient access advantages of an open-bore system with the superior image quality and speed of a high-field scanner. In our series, the HASTE sequence was best suited for MR-guidance of biopsies.