Journal of magnetic resonance imaging : JMRI
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To develop a T1rho-prepared, balanced gradient echo (b-GRE) pulse sequence for rapid three-dimensional (3D) T1rho relaxation mapping within the time constraints of a clinical exam (<10 minutes), examine the effect of acquisition on the measured T1rho relaxation time and optimize 3D T1rho pulse sequences for the knee joint and spine. ⋯ The T1rho-prepared b-GRE acquisition rapidly and reliably accelerates T1rho quantification of tissues offset partially by a TSL-dependent point spread function.
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J Magn Reson Imaging · Sep 2008
Comparative StudyApparent diffusion coefficient values in peripheral and transition zones of the prostate: comparison between normal and malignant prostatic tissues and correlation with histologic grade.
To investigate the utility of apparent diffusion coefficient (ADC) values for discriminating tumor in patients with prostate cancer from normal prostatic tissues in healthy adult men, and to identify correlations between ADC and histologic grade of prostate cancer. ⋯ ADC values appear to provide acceptable diagnostic accuracy in both PZ and TZ.
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J Magn Reson Imaging · Sep 2008
Fast projective carotid MR angiography using arterial spin-labeled balanced SSFP.
To determine whether pulsed arterial spin-labeled (pulsed ASL) balanced steady-state free precession (bSSFP) imaging allows for rapid projective depiction of the carotid arteries without electrocardiographic (ECG) gating. ⋯ pulsed ASL bSSFP is a fast technique for projective carotid angiography that may not require ECG gating. Acquisition time may be decreased with reduced FOV or parallel imaging strategies.
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J Magn Reson Imaging · Sep 2008
Assessment of fluctuating velocities in disturbed cardiovascular blood flow: in vivo feasibility of generalized phase-contrast MRI.
To evaluate the feasibility of generalized phase-contrast magnetic resonance imaging (PC-MRI) for the noninvasive assessment of fluctuating velocities in cardiovascular blood flow. ⋯ PC-MRI IVSD mapping is able to detect flow abnormalities in a variety of human cardiovascular conditions and shows promise for the quantitative assessment of turbulence. This approach may assist in clarifying the role of disturbed hemodynamics in cardiovascular diseases.
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J Magn Reson Imaging · Sep 2008
Dynamic contrast-enhanced (DCE) derived transfer coefficient (ktrans) is a surrogate marker of matrix metalloproteinase 9 (MMP-9) expression in brain tuberculomas.
To correlate dynamic contrast-enhanced (DCE) MRI derived perfusion indices with immunohistochemically obtained vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in a cellular fraction of brain tuberculomas (BT). ⋯ We conclude that the expression of MMP-9, a marker of BBB disruption and disease activity in BT correlates with DCE-derived ktrans and thus has the potential to be used as its surrogate marker.