Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Aug 2009
Evaluating the role of zinc in the occurrence of fibrosis of the skin: a preclinical study.
To investigate the possible role of Zn as a trigger for NSF we were using a previously established preclinical model. The depletion of endogenous Zinc ions (Zn) caused by the administration of gadolinium-based contrast agents (GBCAs) has been suggested as a possible pathomechanism for nephrogenic systemic fibrosis (NSF). ⋯ We found no significant effect of Zn on the initiation of NSF-like skin lesions. The results further support data from previous studies highlighting the importance of complex stability of the investigated GBCAs.